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Human and environmental impacts of nanoparticles: a scoping review of the current literature
Use of nanoparticles have established benefits in a wide range of applications, however, the effects of exposure to nanoparticles on health and the environmental risks associated with the production and use of nanoparticles are less well-established. The present study addresses this gap in knowledge...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239112/ https://www.ncbi.nlm.nih.gov/pubmed/37268899 http://dx.doi.org/10.1186/s12889-023-15958-4 |
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author | Kumah, Elizabeth Adjoa Fopa, Raoul Djou Harati, Saeed Boadu, Paul Zohoori, Fatemeh Vida Pak, Tannaz |
author_facet | Kumah, Elizabeth Adjoa Fopa, Raoul Djou Harati, Saeed Boadu, Paul Zohoori, Fatemeh Vida Pak, Tannaz |
author_sort | Kumah, Elizabeth Adjoa |
collection | PubMed |
description | Use of nanoparticles have established benefits in a wide range of applications, however, the effects of exposure to nanoparticles on health and the environmental risks associated with the production and use of nanoparticles are less well-established. The present study addresses this gap in knowledge by examining, through a scoping review of the current literature, the effects of nanoparticles on human health and the environment. We searched relevant databases including Medline, Web of Science, ScienceDirect, Scopus, CINAHL, Embase, and SAGE journals, as well as Google, Google Scholar, and grey literature from June 2021 to July 2021. After removing duplicate articles, the title and abstracts of 1495 articles were first screened followed by the full-texts of 249 studies, and this resulted in the inclusion of 117 studies in the presented review. In this contribution we conclude that while nanoparticles offer distinct benefits in a range of applications, they pose significant threats to humans and the environment. Using several biological models and biomarkers, the included studies revealed the toxic effects of nanoparticles (mainly zinc oxide, silicon dioxide, titanium dioxide, silver, and carbon nanotubes) to include cell death, production of oxidative stress, DNA damage, apoptosis, and induction of inflammatory responses. Most of the included studies (65.81%) investigated inorganic-based nanoparticles. In terms of biomarkers, most studies (76.9%) used immortalised cell lines, whiles 18.8% used primary cells as the biomarker for assessing human health effect of nanoparticles. Biomarkers that were used for assessing environmental impact of nanoparticles included soil samples and soybean seeds, zebrafish larvae, fish, and Daphnia magna neonates. From the studies included in this work the United States recorded the highest number of publications (n = 30, 25.64%), followed by China, India, and Saudi Arabia recording the same number of publications (n = 8 each), with 95.75% of the studies published from the year 2009. The majority of the included studies (93.16%) assessed impact of nanoparticles on human health, and 95.7% used experimental study design. This shows a clear gap exists in examining the impact of nanoparticles on the environment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-023-15958-4. |
format | Online Article Text |
id | pubmed-10239112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-102391122023-06-04 Human and environmental impacts of nanoparticles: a scoping review of the current literature Kumah, Elizabeth Adjoa Fopa, Raoul Djou Harati, Saeed Boadu, Paul Zohoori, Fatemeh Vida Pak, Tannaz BMC Public Health Research Use of nanoparticles have established benefits in a wide range of applications, however, the effects of exposure to nanoparticles on health and the environmental risks associated with the production and use of nanoparticles are less well-established. The present study addresses this gap in knowledge by examining, through a scoping review of the current literature, the effects of nanoparticles on human health and the environment. We searched relevant databases including Medline, Web of Science, ScienceDirect, Scopus, CINAHL, Embase, and SAGE journals, as well as Google, Google Scholar, and grey literature from June 2021 to July 2021. After removing duplicate articles, the title and abstracts of 1495 articles were first screened followed by the full-texts of 249 studies, and this resulted in the inclusion of 117 studies in the presented review. In this contribution we conclude that while nanoparticles offer distinct benefits in a range of applications, they pose significant threats to humans and the environment. Using several biological models and biomarkers, the included studies revealed the toxic effects of nanoparticles (mainly zinc oxide, silicon dioxide, titanium dioxide, silver, and carbon nanotubes) to include cell death, production of oxidative stress, DNA damage, apoptosis, and induction of inflammatory responses. Most of the included studies (65.81%) investigated inorganic-based nanoparticles. In terms of biomarkers, most studies (76.9%) used immortalised cell lines, whiles 18.8% used primary cells as the biomarker for assessing human health effect of nanoparticles. Biomarkers that were used for assessing environmental impact of nanoparticles included soil samples and soybean seeds, zebrafish larvae, fish, and Daphnia magna neonates. From the studies included in this work the United States recorded the highest number of publications (n = 30, 25.64%), followed by China, India, and Saudi Arabia recording the same number of publications (n = 8 each), with 95.75% of the studies published from the year 2009. The majority of the included studies (93.16%) assessed impact of nanoparticles on human health, and 95.7% used experimental study design. This shows a clear gap exists in examining the impact of nanoparticles on the environment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-023-15958-4. BioMed Central 2023-06-03 /pmc/articles/PMC10239112/ /pubmed/37268899 http://dx.doi.org/10.1186/s12889-023-15958-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Kumah, Elizabeth Adjoa Fopa, Raoul Djou Harati, Saeed Boadu, Paul Zohoori, Fatemeh Vida Pak, Tannaz Human and environmental impacts of nanoparticles: a scoping review of the current literature |
title | Human and environmental impacts of nanoparticles: a scoping review of the current literature |
title_full | Human and environmental impacts of nanoparticles: a scoping review of the current literature |
title_fullStr | Human and environmental impacts of nanoparticles: a scoping review of the current literature |
title_full_unstemmed | Human and environmental impacts of nanoparticles: a scoping review of the current literature |
title_short | Human and environmental impacts of nanoparticles: a scoping review of the current literature |
title_sort | human and environmental impacts of nanoparticles: a scoping review of the current literature |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239112/ https://www.ncbi.nlm.nih.gov/pubmed/37268899 http://dx.doi.org/10.1186/s12889-023-15958-4 |
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