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Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?

Minimum information models are reporting frameworks that describe the essential information that needs to be provided in a publication, so that the work can be repeated or compared to other work. In 2016, Minimum Information about Tolerogenic Antigen-Presenting cells (MITAP) was created to standardi...

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Autores principales: Sahar, Ayesha, Nicorescu, Ioana, Barran, Gabrielle, Paterson, Megan, Hilkens, Catharien M.U., Lord, Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239229/
https://www.ncbi.nlm.nih.gov/pubmed/37273539
http://dx.doi.org/10.7717/peerj.15352
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author Sahar, Ayesha
Nicorescu, Ioana
Barran, Gabrielle
Paterson, Megan
Hilkens, Catharien M.U.
Lord, Phillip
author_facet Sahar, Ayesha
Nicorescu, Ioana
Barran, Gabrielle
Paterson, Megan
Hilkens, Catharien M.U.
Lord, Phillip
author_sort Sahar, Ayesha
collection PubMed
description Minimum information models are reporting frameworks that describe the essential information that needs to be provided in a publication, so that the work can be repeated or compared to other work. In 2016, Minimum Information about Tolerogenic Antigen-Presenting cells (MITAP) was created to standardize the reporting on tolerogenic antigen-presenting cells, including tolerogenic dendritic cells (tolDCs). tolDCs is a generic term for dendritic cells that have the ability to (re-)establish immune tolerance; they have been developed as a cell therapy for autoimmune diseases or for the prevention of transplant rejection. Because protocols to generate these therapeutic cells vary widely, MITAP was deemed to be a pivotal reporting tool by and for the tolDC community. In this paper, we explored the impact that MITAP has had on the tolDC field. We did this by examining a subset of the available literature on tolDCs. Our analysis shows that MITAP is used in only the minority of relevant papers (14%), but where it is used the amount of metadata available is slightly increased over where it is not. From this, we conclude that MITAP has been a partial success, but that much more needs to be done if standardized reporting is to become common within the discipline.
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spelling pubmed-102392292023-06-04 Tolerogenic dendritic cell reporting: Has a minimum information model made a difference? Sahar, Ayesha Nicorescu, Ioana Barran, Gabrielle Paterson, Megan Hilkens, Catharien M.U. Lord, Phillip PeerJ Bioinformatics Minimum information models are reporting frameworks that describe the essential information that needs to be provided in a publication, so that the work can be repeated or compared to other work. In 2016, Minimum Information about Tolerogenic Antigen-Presenting cells (MITAP) was created to standardize the reporting on tolerogenic antigen-presenting cells, including tolerogenic dendritic cells (tolDCs). tolDCs is a generic term for dendritic cells that have the ability to (re-)establish immune tolerance; they have been developed as a cell therapy for autoimmune diseases or for the prevention of transplant rejection. Because protocols to generate these therapeutic cells vary widely, MITAP was deemed to be a pivotal reporting tool by and for the tolDC community. In this paper, we explored the impact that MITAP has had on the tolDC field. We did this by examining a subset of the available literature on tolDCs. Our analysis shows that MITAP is used in only the minority of relevant papers (14%), but where it is used the amount of metadata available is slightly increased over where it is not. From this, we conclude that MITAP has been a partial success, but that much more needs to be done if standardized reporting is to become common within the discipline. PeerJ Inc. 2023-05-31 /pmc/articles/PMC10239229/ /pubmed/37273539 http://dx.doi.org/10.7717/peerj.15352 Text en ©2023 Sahar et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Bioinformatics
Sahar, Ayesha
Nicorescu, Ioana
Barran, Gabrielle
Paterson, Megan
Hilkens, Catharien M.U.
Lord, Phillip
Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?
title Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?
title_full Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?
title_fullStr Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?
title_full_unstemmed Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?
title_short Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?
title_sort tolerogenic dendritic cell reporting: has a minimum information model made a difference?
topic Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239229/
https://www.ncbi.nlm.nih.gov/pubmed/37273539
http://dx.doi.org/10.7717/peerj.15352
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