Pimavanserin: A Truly Effective Treatment for Parkinson’s Disease Psychosis? A Review of Interventions

Parkinson’s disease (PD) is the second-most common neurodegenerative disorder with a long-term 60% cumulative prevalence of PD psychosis. Medical treatment is limited to few atypical antipsychotic drugs with low affinity to dopamine D2 receptors. In 2016, pimavanserin, a selective 5-HT2A inverse ago...

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Detalles Bibliográficos
Autores principales: Heim, Beatrice, Peball, Marina, Krismer, Florian, Djamshidian, Atbin, Seppi, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239266/
https://www.ncbi.nlm.nih.gov/pubmed/37274140
http://dx.doi.org/10.2147/NDT.S371641
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author Heim, Beatrice
Peball, Marina
Krismer, Florian
Djamshidian, Atbin
Seppi, Klaus
author_facet Heim, Beatrice
Peball, Marina
Krismer, Florian
Djamshidian, Atbin
Seppi, Klaus
author_sort Heim, Beatrice
collection PubMed
description Parkinson’s disease (PD) is the second-most common neurodegenerative disorder with a long-term 60% cumulative prevalence of PD psychosis. Medical treatment is limited to few atypical antipsychotic drugs with low affinity to dopamine D2 receptors. In 2016, pimavanserin, a selective 5-HT2A inverse agonist/antagonist, was approved by the US Food and Drug Administration (FDA) as the only treatment for PD psychosis (PDP). This article provides an overview of the epidemiology, pathophysiology, and treatment options for PDP and illuminates the mode of action and therapy options with pimavanserin and the current study data.
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spelling pubmed-102392662023-06-04 Pimavanserin: A Truly Effective Treatment for Parkinson’s Disease Psychosis? A Review of Interventions Heim, Beatrice Peball, Marina Krismer, Florian Djamshidian, Atbin Seppi, Klaus Neuropsychiatr Dis Treat Review Parkinson’s disease (PD) is the second-most common neurodegenerative disorder with a long-term 60% cumulative prevalence of PD psychosis. Medical treatment is limited to few atypical antipsychotic drugs with low affinity to dopamine D2 receptors. In 2016, pimavanserin, a selective 5-HT2A inverse agonist/antagonist, was approved by the US Food and Drug Administration (FDA) as the only treatment for PD psychosis (PDP). This article provides an overview of the epidemiology, pathophysiology, and treatment options for PDP and illuminates the mode of action and therapy options with pimavanserin and the current study data. Dove 2023-05-30 /pmc/articles/PMC10239266/ /pubmed/37274140 http://dx.doi.org/10.2147/NDT.S371641 Text en © 2023 Heim et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Heim, Beatrice
Peball, Marina
Krismer, Florian
Djamshidian, Atbin
Seppi, Klaus
Pimavanserin: A Truly Effective Treatment for Parkinson’s Disease Psychosis? A Review of Interventions
title Pimavanserin: A Truly Effective Treatment for Parkinson’s Disease Psychosis? A Review of Interventions
title_full Pimavanserin: A Truly Effective Treatment for Parkinson’s Disease Psychosis? A Review of Interventions
title_fullStr Pimavanserin: A Truly Effective Treatment for Parkinson’s Disease Psychosis? A Review of Interventions
title_full_unstemmed Pimavanserin: A Truly Effective Treatment for Parkinson’s Disease Psychosis? A Review of Interventions
title_short Pimavanserin: A Truly Effective Treatment for Parkinson’s Disease Psychosis? A Review of Interventions
title_sort pimavanserin: a truly effective treatment for parkinson’s disease psychosis? a review of interventions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239266/
https://www.ncbi.nlm.nih.gov/pubmed/37274140
http://dx.doi.org/10.2147/NDT.S371641
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