Overexpression of fatty acid synthase attenuates bleomycin induced lung fibrosis by restoring mitochondrial dysfunction in mice

Proper lipid metabolism is crucial to maintain alveolar epithelial cell (AEC) function, and excessive AEC death plays a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The mRNA expression of fatty acid synthase (FASN), a key enzyme in the production of palmitate and other fatty acid...

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Detalles Bibliográficos
Autores principales: Shin, Hyesun, Park, Shinhee, Hong, Jisu, Baek, Ae-Rin, Lee, Junehyuk, Kim, Do-Jin, Jang, An-Soo, Chin, Su Sie, Jeong, Sung Hwan, Park, Sung-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239437/
https://www.ncbi.nlm.nih.gov/pubmed/37270622
http://dx.doi.org/10.1038/s41598-023-36009-3

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