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Intrinsic TGF-β signaling attenuates proximal tubule mitochondrial injury and inflammation in chronic kidney disease

Excessive TGF-β signaling and mitochondrial dysfunction fuel chronic kidney disease (CKD) progression. However, inhibiting TGF-β failed to impede CKD in humans. The proximal tubule (PT), the most vulnerable renal segment, is packed with giant mitochondria and injured PT is pivotal in CKD progression...

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Detalles Bibliográficos
Autores principales:	Kayhan, Merve, Vouillamoz, Judith, Rodriguez, Daymé Gonzalez, Bugarski, Milica, Mitamura, Yasutaka, Gschwend, Julia, Schneider, Christoph, Hall, Andrew, Legouis, David, Akdis, Cezmi A., Peter, Leary, Rehrauer, Hubert, Gewin, Leslie, Wenger, Roland H., Khodo, Stellor Nlandu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239443/ https://www.ncbi.nlm.nih.gov/pubmed/37270534 http://dx.doi.org/10.1038/s41467-023-39050-y

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