Lysophosphatidic acid modulates CD8 T cell immunosurveillance and metabolism to impair anti-tumor immunity

Lysophosphatidic acid (LPA) is a bioactive lipid which increases in concentration locally and systemically across different cancer types. Yet, the exact mechanism(s) of how LPA affects CD8 T cell immunosurveillance during tumor progression remain unknown. We show LPA receptor (LPAR) signaling by CD8...

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Detalles Bibliográficos
Autores principales: Turner, Jacqueline A., Fredrickson, Malia A., D’Antonio, Marc, Katsnelson, Elizabeth, MacBeth, Morgan, Van Gulick, Robert, Chimed, Tugs-Saikhan, McCarter, Martin, D’Alessandro, Angelo, Robinson, William A., Couts, Kasey L., Pelanda, Roberta, Klarquist, Jared, Tobin, Richard P., Torres, Raul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239450/
https://www.ncbi.nlm.nih.gov/pubmed/37270644
http://dx.doi.org/10.1038/s41467-023-38933-4

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