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Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration

Conventional treatment to periodontal and many other bone defects requires the use of barrier membranes to guided tissue regeneration (GTR) and guided bone regeneration (GBR). However, current barrier membranes normally lack of the ability to actively regulate the bone repairing process. Herein, we...

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Autores principales: Zhang, Yaping, Chen, Yi, Ding, Tian, Zhang, Yandi, Yang, Daiwei, Zhao, Yajun, Liu, Jin, Ma, Baojin, Bianco, Alberto, Ge, Shaohua, Li, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239453/
https://www.ncbi.nlm.nih.gov/pubmed/37270633
http://dx.doi.org/10.1038/s41536-023-00305-3
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author Zhang, Yaping
Chen, Yi
Ding, Tian
Zhang, Yandi
Yang, Daiwei
Zhao, Yajun
Liu, Jin
Ma, Baojin
Bianco, Alberto
Ge, Shaohua
Li, Jianhua
author_facet Zhang, Yaping
Chen, Yi
Ding, Tian
Zhang, Yandi
Yang, Daiwei
Zhao, Yajun
Liu, Jin
Ma, Baojin
Bianco, Alberto
Ge, Shaohua
Li, Jianhua
author_sort Zhang, Yaping
collection PubMed
description Conventional treatment to periodontal and many other bone defects requires the use of barrier membranes to guided tissue regeneration (GTR) and guided bone regeneration (GBR). However, current barrier membranes normally lack of the ability to actively regulate the bone repairing process. Herein, we proposed a biomimetic bone tissue engineering strategy enabled by a new type of Janus porous polylactic acid membrane (PLAM), which was fabricated by combining unidirectional evaporation-induced pore formation with subsequent self-assembly of a bioactive metal–phenolic network (MPN) nanointerface. The prepared PLAM-MPN simultaneously possesses barrier function on the dense side and bone-forming function on the porous side. In vitro, the presence of MPN nanointerface potently alleviated the proinflammatory polarization of mice bone marrow-derived macrophages (BMDMs), induced angiogenesis of human umbilical vein endothelial cells (HUVECs), and enhanced the attachment, migration and osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs). The implantation of PLAM-MPN into rat periodontal bone defects remarkably enhanced bone regeneration. This bioactive MPN nanointerface within a Janus porous membrane possesses versatile capacities to regulate cell physiology favoring bone regeneration, demonstrating great potential as GTR and GBR membranes for clinical applications.
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spelling pubmed-102394532023-06-05 Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration Zhang, Yaping Chen, Yi Ding, Tian Zhang, Yandi Yang, Daiwei Zhao, Yajun Liu, Jin Ma, Baojin Bianco, Alberto Ge, Shaohua Li, Jianhua NPJ Regen Med Article Conventional treatment to periodontal and many other bone defects requires the use of barrier membranes to guided tissue regeneration (GTR) and guided bone regeneration (GBR). However, current barrier membranes normally lack of the ability to actively regulate the bone repairing process. Herein, we proposed a biomimetic bone tissue engineering strategy enabled by a new type of Janus porous polylactic acid membrane (PLAM), which was fabricated by combining unidirectional evaporation-induced pore formation with subsequent self-assembly of a bioactive metal–phenolic network (MPN) nanointerface. The prepared PLAM-MPN simultaneously possesses barrier function on the dense side and bone-forming function on the porous side. In vitro, the presence of MPN nanointerface potently alleviated the proinflammatory polarization of mice bone marrow-derived macrophages (BMDMs), induced angiogenesis of human umbilical vein endothelial cells (HUVECs), and enhanced the attachment, migration and osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs). The implantation of PLAM-MPN into rat periodontal bone defects remarkably enhanced bone regeneration. This bioactive MPN nanointerface within a Janus porous membrane possesses versatile capacities to regulate cell physiology favoring bone regeneration, demonstrating great potential as GTR and GBR membranes for clinical applications. Nature Publishing Group UK 2023-06-03 /pmc/articles/PMC10239453/ /pubmed/37270633 http://dx.doi.org/10.1038/s41536-023-00305-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhang, Yaping
Chen, Yi
Ding, Tian
Zhang, Yandi
Yang, Daiwei
Zhao, Yajun
Liu, Jin
Ma, Baojin
Bianco, Alberto
Ge, Shaohua
Li, Jianhua
Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration
title Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration
title_full Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration
title_fullStr Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration
title_full_unstemmed Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration
title_short Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration
title_sort janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239453/
https://www.ncbi.nlm.nih.gov/pubmed/37270633
http://dx.doi.org/10.1038/s41536-023-00305-3
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