APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors

The cytidine deaminase, Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B, herein termed A3B), is a critical mutation driver that induces genomic instability in cancer by catalyzing cytosine-to-thymine (C-to-T) conversion and promoting replication stress (RS). However, the detailed...

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Detalles Bibliográficos
Autores principales: Zong, Chunyan, Zhang, Zhe, Gao, Li, He, Jie, Wang, Yiran, Li, Qian, Liu, Xiaoting, Yang, Jie, Chen, Di, Huang, Rui, Zheng, Guopei, Jin, Xiaoliang, Wei, Wu, Jia, Renbing, Shen, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239489/
https://www.ncbi.nlm.nih.gov/pubmed/37270643
http://dx.doi.org/10.1038/s41419-023-05867-0

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