Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding

Compared to most ATP-site kinase inhibitors, small molecules that target an allosteric pocket have the potential for improved selectivity due to the often observed lower structural similarity at these distal sites. Despite their promise, relatively few examples of structurally confirmed, high-affini...

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Detalles Bibliográficos
Autores principales: Faber, Erik B., Sun, Luxin, Tang, Jian, Roberts, Emily, Ganeshkumar, Sornakala, Wang, Nan, Rasmussen, Damien, Majumdar, Abir, Hirsch, Laura E., John, Kristen, Yang, An, Khalid, Hira, Hawkinson, Jon E., Levinson, Nicholas M., Chennathukuzhi, Vargheese, Harki, Daniel A., Schönbrunn, Ernst, Georg, Gunda I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239507/
https://www.ncbi.nlm.nih.gov/pubmed/37270540
http://dx.doi.org/10.1038/s41467-023-38732-x

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