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A Case of Isolated Renal Light Chain Amyloidosis With Hematuria and Low Complement Levels

The prevalence of light chain (AL) amyloidosis, characterized by the deposition of amyloid chains, is gradually increasing. The clinical features of the disease depend upon the location of amyloid deposition and can manifest in many forms. Although laboratory investigations can reveal proteinuria an...

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Detalles Bibliográficos
Autores principales: Javed, Nismat, Uday, Kalpana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239556/
https://www.ncbi.nlm.nih.gov/pubmed/37284407
http://dx.doi.org/10.7759/cureus.38572
Descripción
Sumario:The prevalence of light chain (AL) amyloidosis, characterized by the deposition of amyloid chains, is gradually increasing. The clinical features of the disease depend upon the location of amyloid deposition and can manifest in many forms. Although laboratory investigations can reveal proteinuria and change in complement levels, hematuria and low complement levels are rarely reported. There are very few cases of renal AL amyloidosis presenting as persistent hematuria. We present the case of a 54-year-old female presenting with abdominal pain, proteinuria, and moderate persistent hematuria on admission who was later diagnosed with AL amyloidosis on biopsy.