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Neonatal portal vein thrombosis: risk factors, diagnosis, treatment recommendations and review of the literature
BACKGROUND: Neonatal portal vein thrombosis (PVT) is currently more commonly encountered as a result of advances in diagnostic tools and increase in invasive interventions. METHODS: In this study, 11 premature and 12 term infants diagnosed with PVT were retrospectively evaluated for clinical and lab...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239671/ https://www.ncbi.nlm.nih.gov/pubmed/37271816 http://dx.doi.org/10.1186/s12959-023-00508-0 |
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author | Solgun, Huseyin Avni Uysalol, Ezgi Paslı Bayram, Cengiz Terzi, Özlem Çetinkaya, Merih Memur, Şeyma Aycicek, Ali |
author_facet | Solgun, Huseyin Avni Uysalol, Ezgi Paslı Bayram, Cengiz Terzi, Özlem Çetinkaya, Merih Memur, Şeyma Aycicek, Ali |
author_sort | Solgun, Huseyin Avni |
collection | PubMed |
description | BACKGROUND: Neonatal portal vein thrombosis (PVT) is currently more commonly encountered as a result of advances in diagnostic tools and increase in invasive interventions. METHODS: In this study, 11 premature and 12 term infants diagnosed with PVT were retrospectively evaluated for clinical and laboratory characteristics, umbilical catheterization procedure, PVT location, risk factors, treatments, and long-term outcomes. RESULTS: Median age of the patients at diagnosis was 10 days (range 3–90 days), and 69.6% of patients were girls. Of the 23 patients, 87% had left PVT and, 91.3% had at least one thrombosis risk factor, which was sepsis in 73.9% of patients, and presence of umbilical venous catheter in 87%. Totally, 59.1% of PVTs were completely resolved in a median follow-up of 7 months (1 month to 12 months), and 78.3% of these patients had no anticoagulant therapy (ACT). Partial thrombus resolution was achieved in 9 patients (40.9%). Five patients (%21) received ACT. Overall, 34.8% of patients had long-term complications. neonatal PVT is most commonly reported in the left portal vein and there is no evidence for the impact of ACT on reducing the short- or long-term complications. Well designed and larger studies are necessary to clarify this issue, which can facilitate developing appropriate management algorithms. CONCLUSION: Neonatal PVT is most commonly reported in the left portal vein and there is no evidence for the impact of ACT on reducing the short- or long-term complications. Well designed and larger studies are necessary to clarify this issue, which can facilitate developing appropriate management algorithms. |
format | Online Article Text |
id | pubmed-10239671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-102396712023-06-06 Neonatal portal vein thrombosis: risk factors, diagnosis, treatment recommendations and review of the literature Solgun, Huseyin Avni Uysalol, Ezgi Paslı Bayram, Cengiz Terzi, Özlem Çetinkaya, Merih Memur, Şeyma Aycicek, Ali Thromb J Research BACKGROUND: Neonatal portal vein thrombosis (PVT) is currently more commonly encountered as a result of advances in diagnostic tools and increase in invasive interventions. METHODS: In this study, 11 premature and 12 term infants diagnosed with PVT were retrospectively evaluated for clinical and laboratory characteristics, umbilical catheterization procedure, PVT location, risk factors, treatments, and long-term outcomes. RESULTS: Median age of the patients at diagnosis was 10 days (range 3–90 days), and 69.6% of patients were girls. Of the 23 patients, 87% had left PVT and, 91.3% had at least one thrombosis risk factor, which was sepsis in 73.9% of patients, and presence of umbilical venous catheter in 87%. Totally, 59.1% of PVTs were completely resolved in a median follow-up of 7 months (1 month to 12 months), and 78.3% of these patients had no anticoagulant therapy (ACT). Partial thrombus resolution was achieved in 9 patients (40.9%). Five patients (%21) received ACT. Overall, 34.8% of patients had long-term complications. neonatal PVT is most commonly reported in the left portal vein and there is no evidence for the impact of ACT on reducing the short- or long-term complications. Well designed and larger studies are necessary to clarify this issue, which can facilitate developing appropriate management algorithms. CONCLUSION: Neonatal PVT is most commonly reported in the left portal vein and there is no evidence for the impact of ACT on reducing the short- or long-term complications. Well designed and larger studies are necessary to clarify this issue, which can facilitate developing appropriate management algorithms. BioMed Central 2023-06-05 /pmc/articles/PMC10239671/ /pubmed/37271816 http://dx.doi.org/10.1186/s12959-023-00508-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Solgun, Huseyin Avni Uysalol, Ezgi Paslı Bayram, Cengiz Terzi, Özlem Çetinkaya, Merih Memur, Şeyma Aycicek, Ali Neonatal portal vein thrombosis: risk factors, diagnosis, treatment recommendations and review of the literature |
title | Neonatal portal vein thrombosis: risk factors, diagnosis, treatment recommendations and review of the literature |
title_full | Neonatal portal vein thrombosis: risk factors, diagnosis, treatment recommendations and review of the literature |
title_fullStr | Neonatal portal vein thrombosis: risk factors, diagnosis, treatment recommendations and review of the literature |
title_full_unstemmed | Neonatal portal vein thrombosis: risk factors, diagnosis, treatment recommendations and review of the literature |
title_short | Neonatal portal vein thrombosis: risk factors, diagnosis, treatment recommendations and review of the literature |
title_sort | neonatal portal vein thrombosis: risk factors, diagnosis, treatment recommendations and review of the literature |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239671/ https://www.ncbi.nlm.nih.gov/pubmed/37271816 http://dx.doi.org/10.1186/s12959-023-00508-0 |
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