The emerging roles and mechanism of N6-methyladenosine (m(6)A) modifications in urologic tumours progression

Prostate cancer (PCa), bladder cancer (BC), and renal cell cancer (RCC) are the most common urologic tumours in males. N6-methyladenosine (m(6)A), adenosine N6 methylation, is the most prevalent RNA modification in mammals. Increasing evidence suggests that m(6)A plays a crucial role in cancer devel...

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Autores principales: Zhu, Wenhao, Zhao, Renshan, Guan, Xiaomin, Wang, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239868/
https://www.ncbi.nlm.nih.gov/pubmed/37284313
http://dx.doi.org/10.3389/fphar.2023.1192495
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author Zhu, Wenhao
Zhao, Renshan
Guan, Xiaomin
Wang, Xu
author_facet Zhu, Wenhao
Zhao, Renshan
Guan, Xiaomin
Wang, Xu
author_sort Zhu, Wenhao
collection PubMed
description Prostate cancer (PCa), bladder cancer (BC), and renal cell cancer (RCC) are the most common urologic tumours in males. N6-methyladenosine (m(6)A), adenosine N6 methylation, is the most prevalent RNA modification in mammals. Increasing evidence suggests that m(6)A plays a crucial role in cancer development. In this review, we comprehensively analyzed the influence of m(6)A methylation on Prostate cancer, bladder cancer, and renal cell cancer and the relationship between the expression of relevant regulatory factors and their development and occurrence, which provides new insights and approaches for the early clinical diagnosis and targeted therapy of urologic malignancies.
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spelling pubmed-102398682023-06-06 The emerging roles and mechanism of N6-methyladenosine (m(6)A) modifications in urologic tumours progression Zhu, Wenhao Zhao, Renshan Guan, Xiaomin Wang, Xu Front Pharmacol Pharmacology Prostate cancer (PCa), bladder cancer (BC), and renal cell cancer (RCC) are the most common urologic tumours in males. N6-methyladenosine (m(6)A), adenosine N6 methylation, is the most prevalent RNA modification in mammals. Increasing evidence suggests that m(6)A plays a crucial role in cancer development. In this review, we comprehensively analyzed the influence of m(6)A methylation on Prostate cancer, bladder cancer, and renal cell cancer and the relationship between the expression of relevant regulatory factors and their development and occurrence, which provides new insights and approaches for the early clinical diagnosis and targeted therapy of urologic malignancies. Frontiers Media S.A. 2023-05-22 /pmc/articles/PMC10239868/ /pubmed/37284313 http://dx.doi.org/10.3389/fphar.2023.1192495 Text en Copyright © 2023 Zhu, Zhao, Guan and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhu, Wenhao
Zhao, Renshan
Guan, Xiaomin
Wang, Xu
The emerging roles and mechanism of N6-methyladenosine (m(6)A) modifications in urologic tumours progression
title The emerging roles and mechanism of N6-methyladenosine (m(6)A) modifications in urologic tumours progression
title_full The emerging roles and mechanism of N6-methyladenosine (m(6)A) modifications in urologic tumours progression
title_fullStr The emerging roles and mechanism of N6-methyladenosine (m(6)A) modifications in urologic tumours progression
title_full_unstemmed The emerging roles and mechanism of N6-methyladenosine (m(6)A) modifications in urologic tumours progression
title_short The emerging roles and mechanism of N6-methyladenosine (m(6)A) modifications in urologic tumours progression
title_sort emerging roles and mechanism of n6-methyladenosine (m(6)a) modifications in urologic tumours progression
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239868/
https://www.ncbi.nlm.nih.gov/pubmed/37284313
http://dx.doi.org/10.3389/fphar.2023.1192495
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