A case report of early diagnosis of asymptomatic hairy cell leukemia using flow cytometry

Hairy Cell Leukemia is an infrequent leukemia that can be recognized both microscopically and flow cytometrically once the patient develops symptoms. We present a case where early diagnosis was achieved using flow cytometry long before the patient became symptomatic. This was achieved by focusing on...

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Autores principales: Tadros, James, Davis, Amanda, Awoleye, Oreoluwa, Vassiliou, Evros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239883/
https://www.ncbi.nlm.nih.gov/pubmed/37283771
http://dx.doi.org/10.3389/fimmu.2023.1207443
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author Tadros, James
Davis, Amanda
Awoleye, Oreoluwa
Vassiliou, Evros
author_facet Tadros, James
Davis, Amanda
Awoleye, Oreoluwa
Vassiliou, Evros
author_sort Tadros, James
collection PubMed
description Hairy Cell Leukemia is an infrequent leukemia that can be recognized both microscopically and flow cytometrically once the patient develops symptoms. We present a case where early diagnosis was achieved using flow cytometry long before the patient became symptomatic. This was achieved by focusing on a small percentage (0.9%) of total leukocytes that exhibited a higher side scatter and brighter CD19/CD20 than the remaining lymphocytes. A bone marrow aspirate three weeks later confirmed the presence of malignant B-cells. Shortly after, the patient presented splenomegaly and complained of fatigue.
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spelling pubmed-102398832023-06-06 A case report of early diagnosis of asymptomatic hairy cell leukemia using flow cytometry Tadros, James Davis, Amanda Awoleye, Oreoluwa Vassiliou, Evros Front Immunol Immunology Hairy Cell Leukemia is an infrequent leukemia that can be recognized both microscopically and flow cytometrically once the patient develops symptoms. We present a case where early diagnosis was achieved using flow cytometry long before the patient became symptomatic. This was achieved by focusing on a small percentage (0.9%) of total leukocytes that exhibited a higher side scatter and brighter CD19/CD20 than the remaining lymphocytes. A bone marrow aspirate three weeks later confirmed the presence of malignant B-cells. Shortly after, the patient presented splenomegaly and complained of fatigue. Frontiers Media S.A. 2023-05-22 /pmc/articles/PMC10239883/ /pubmed/37283771 http://dx.doi.org/10.3389/fimmu.2023.1207443 Text en Copyright © 2023 Tadros, Davis, Awoleye and Vassiliou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tadros, James
Davis, Amanda
Awoleye, Oreoluwa
Vassiliou, Evros
A case report of early diagnosis of asymptomatic hairy cell leukemia using flow cytometry
title A case report of early diagnosis of asymptomatic hairy cell leukemia using flow cytometry
title_full A case report of early diagnosis of asymptomatic hairy cell leukemia using flow cytometry
title_fullStr A case report of early diagnosis of asymptomatic hairy cell leukemia using flow cytometry
title_full_unstemmed A case report of early diagnosis of asymptomatic hairy cell leukemia using flow cytometry
title_short A case report of early diagnosis of asymptomatic hairy cell leukemia using flow cytometry
title_sort case report of early diagnosis of asymptomatic hairy cell leukemia using flow cytometry
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239883/
https://www.ncbi.nlm.nih.gov/pubmed/37283771
http://dx.doi.org/10.3389/fimmu.2023.1207443
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