The role of Raptor in lymphocytes differentiation and function

Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cell...

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Autores principales: Tang, Jianing, Yang, Lu, Guan, Fei, Miller, Heather, Camara, Niels Olsen Saraiva, James, Louisa K., Benlagha, Kamel, Kubo, Masato, Heegaard, Steffen, Lee, Pamela, Lei, Jiahui, Zeng, Hu, He, Chengwei, Zhai, Zhimin, Liu, Chaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239924/
https://www.ncbi.nlm.nih.gov/pubmed/37283744
http://dx.doi.org/10.3389/fimmu.2023.1146628
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author Tang, Jianing
Yang, Lu
Guan, Fei
Miller, Heather
Camara, Niels Olsen Saraiva
James, Louisa K.
Benlagha, Kamel
Kubo, Masato
Heegaard, Steffen
Lee, Pamela
Lei, Jiahui
Zeng, Hu
He, Chengwei
Zhai, Zhimin
Liu, Chaohong
author_facet Tang, Jianing
Yang, Lu
Guan, Fei
Miller, Heather
Camara, Niels Olsen Saraiva
James, Louisa K.
Benlagha, Kamel
Kubo, Masato
Heegaard, Steffen
Lee, Pamela
Lei, Jiahui
Zeng, Hu
He, Chengwei
Zhai, Zhimin
Liu, Chaohong
author_sort Tang, Jianing
collection PubMed
description Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation.
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spelling pubmed-102399242023-06-06 The role of Raptor in lymphocytes differentiation and function Tang, Jianing Yang, Lu Guan, Fei Miller, Heather Camara, Niels Olsen Saraiva James, Louisa K. Benlagha, Kamel Kubo, Masato Heegaard, Steffen Lee, Pamela Lei, Jiahui Zeng, Hu He, Chengwei Zhai, Zhimin Liu, Chaohong Front Immunol Immunology Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation. Frontiers Media S.A. 2023-05-22 /pmc/articles/PMC10239924/ /pubmed/37283744 http://dx.doi.org/10.3389/fimmu.2023.1146628 Text en Copyright © 2023 Tang, Yang, Guan, Miller, Camara, James, Benlagha, Kubo, Heegaard, Lee, Lei, Zeng, He, Zhai and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tang, Jianing
Yang, Lu
Guan, Fei
Miller, Heather
Camara, Niels Olsen Saraiva
James, Louisa K.
Benlagha, Kamel
Kubo, Masato
Heegaard, Steffen
Lee, Pamela
Lei, Jiahui
Zeng, Hu
He, Chengwei
Zhai, Zhimin
Liu, Chaohong
The role of Raptor in lymphocytes differentiation and function
title The role of Raptor in lymphocytes differentiation and function
title_full The role of Raptor in lymphocytes differentiation and function
title_fullStr The role of Raptor in lymphocytes differentiation and function
title_full_unstemmed The role of Raptor in lymphocytes differentiation and function
title_short The role of Raptor in lymphocytes differentiation and function
title_sort role of raptor in lymphocytes differentiation and function
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239924/
https://www.ncbi.nlm.nih.gov/pubmed/37283744
http://dx.doi.org/10.3389/fimmu.2023.1146628
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