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Estimation of dihydroartemisinin in human plasma using a highly sensitive LTQ Orbitrap mass spectrometer with Xcalibur software

Background: Artemether (ARM), the O-methyl ether prodrug of dihydroartemisinin (DHA), is considered a first-line antimalarial agent. Artemether is extensively metabolized in vivo to its active metabolite DHA, and therefore its determination offers considerable difficulties. In the present study, DHA...

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Detalles Bibliográficos
Autores principales:	Abu-Izneid, Tareq, Abbas, Muhammad, Watson, David G., Shah, Yasar, Shah, Sayyed I., Khuda, Fazli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239939/ https://www.ncbi.nlm.nih.gov/pubmed/37284315 http://dx.doi.org/10.3389/fphar.2023.1157604

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