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Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response

An effective HIV vaccine likely requires the elicitation of neutralizing antibodies (NAbs) against multiple HIV-1 clades. The recently developed cleavage-independent native flexibly linked (NFL) envelope (Env) trimers exhibit well-ordered conformation and elicit autologous tier 2 NAbs in multiple an...

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Detalles Bibliográficos
Autores principales:	Bale, Shridhar, Yang, Lifei, Alirezaei, Mehrdad, Wilson, Richard, Ota, Takayuki, Doyle, Esmeralda D., Cottrell, Christopher A., Guenaga, Javier, Tran, Karen, Li, Wenjuan, Stamatatos, Leonidas, Nemazee, David, Ward, Andrew B., Wyatt, Richard T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239957/ https://www.ncbi.nlm.nih.gov/pubmed/37283743 http://dx.doi.org/10.3389/fimmu.2023.1180959

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