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Early acute cerebellar ataxia after meningococcal B vaccine: a case report of a 7-month-old infant and a review of the literature

Acute cerebellar ataxia (ACA) and acute cerebellitis represent disorders characterized by a para-infectious, post-infectious, or post-vaccination cerebellar inflammation. They are relatively common neurologic disorders among children, and may follow infections, or, more rarely, vaccinations. Few cas...

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Autores principales: Monzani, Nicola Adriano, Corsello, Antonio, Tagliabue, Claudia, Pinzani, Raffaella, Mauri, Eleonora, Agostoni, Carlo, Milani, Gregorio Paolo, Dilena, Robertino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240103/
https://www.ncbi.nlm.nih.gov/pubmed/37277843
http://dx.doi.org/10.1186/s13052-023-01480-1
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author Monzani, Nicola Adriano
Corsello, Antonio
Tagliabue, Claudia
Pinzani, Raffaella
Mauri, Eleonora
Agostoni, Carlo
Milani, Gregorio Paolo
Dilena, Robertino
author_facet Monzani, Nicola Adriano
Corsello, Antonio
Tagliabue, Claudia
Pinzani, Raffaella
Mauri, Eleonora
Agostoni, Carlo
Milani, Gregorio Paolo
Dilena, Robertino
author_sort Monzani, Nicola Adriano
collection PubMed
description Acute cerebellar ataxia (ACA) and acute cerebellitis represent disorders characterized by a para-infectious, post-infectious, or post-vaccination cerebellar inflammation. They are relatively common neurologic disorders among children, and may follow infections, or, more rarely, vaccinations. Few cases are instead described among infants. Although the immunization with meningococcal group B (MenB) vaccine has been associated with some neurological side effects, suspected ACA has been reported only once in the literature. Case presentation: we describe a 7-month-old female that presented ACA within 24 h from the MenB second dose vaccination. Extensive laboratory studies and magnetic resonance imaging excluded other causes. We then conducted an extended review of other vaccine related cases reported in the literature, focusing on the clinical characteristics of ACA and finding that ataxia and cerebellitis of para- or post-infectious cause are very rarely described in the first year of life. We collected 20 articles published in the last 30 years, including an amount of 1663 patients (1–24 years) with ACA. Conclusions: a very small number of suspected post-vaccinal ataxias has been described in recent years, compared to other causes, and vaccination remains an unquestionable medical need. Further research is needed to clarify the complex pathogenesis of this disorder and its eventual link with vaccinations.
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spelling pubmed-102401032023-06-06 Early acute cerebellar ataxia after meningococcal B vaccine: a case report of a 7-month-old infant and a review of the literature Monzani, Nicola Adriano Corsello, Antonio Tagliabue, Claudia Pinzani, Raffaella Mauri, Eleonora Agostoni, Carlo Milani, Gregorio Paolo Dilena, Robertino Ital J Pediatr Case Report Acute cerebellar ataxia (ACA) and acute cerebellitis represent disorders characterized by a para-infectious, post-infectious, or post-vaccination cerebellar inflammation. They are relatively common neurologic disorders among children, and may follow infections, or, more rarely, vaccinations. Few cases are instead described among infants. Although the immunization with meningococcal group B (MenB) vaccine has been associated with some neurological side effects, suspected ACA has been reported only once in the literature. Case presentation: we describe a 7-month-old female that presented ACA within 24 h from the MenB second dose vaccination. Extensive laboratory studies and magnetic resonance imaging excluded other causes. We then conducted an extended review of other vaccine related cases reported in the literature, focusing on the clinical characteristics of ACA and finding that ataxia and cerebellitis of para- or post-infectious cause are very rarely described in the first year of life. We collected 20 articles published in the last 30 years, including an amount of 1663 patients (1–24 years) with ACA. Conclusions: a very small number of suspected post-vaccinal ataxias has been described in recent years, compared to other causes, and vaccination remains an unquestionable medical need. Further research is needed to clarify the complex pathogenesis of this disorder and its eventual link with vaccinations. BioMed Central 2023-06-05 /pmc/articles/PMC10240103/ /pubmed/37277843 http://dx.doi.org/10.1186/s13052-023-01480-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Monzani, Nicola Adriano
Corsello, Antonio
Tagliabue, Claudia
Pinzani, Raffaella
Mauri, Eleonora
Agostoni, Carlo
Milani, Gregorio Paolo
Dilena, Robertino
Early acute cerebellar ataxia after meningococcal B vaccine: a case report of a 7-month-old infant and a review of the literature
title Early acute cerebellar ataxia after meningococcal B vaccine: a case report of a 7-month-old infant and a review of the literature
title_full Early acute cerebellar ataxia after meningococcal B vaccine: a case report of a 7-month-old infant and a review of the literature
title_fullStr Early acute cerebellar ataxia after meningococcal B vaccine: a case report of a 7-month-old infant and a review of the literature
title_full_unstemmed Early acute cerebellar ataxia after meningococcal B vaccine: a case report of a 7-month-old infant and a review of the literature
title_short Early acute cerebellar ataxia after meningococcal B vaccine: a case report of a 7-month-old infant and a review of the literature
title_sort early acute cerebellar ataxia after meningococcal b vaccine: a case report of a 7-month-old infant and a review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240103/
https://www.ncbi.nlm.nih.gov/pubmed/37277843
http://dx.doi.org/10.1186/s13052-023-01480-1
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