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SR-B1-/-ApoE-R61h/h Mice Mimic Human Coronary Heart Disease
Cardiovascular diseases are the leading cause of death in the modern world. Atherosclerosis underlies the majority of these pathologies and may result in sudden life-threatening events such as myocardial infarction or stroke. Current concepts consider a rupture (resp. erosion) of “unstable/vulnerabl...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer US
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240136/ https://www.ncbi.nlm.nih.gov/pubmed/37273155 http://dx.doi.org/10.1007/s10557-023-07475-8 |
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author | Staršíchová, Andrea |
author_facet | Staršíchová, Andrea |
author_sort | Staršíchová, Andrea |
collection | PubMed |
description | Cardiovascular diseases are the leading cause of death in the modern world. Atherosclerosis underlies the majority of these pathologies and may result in sudden life-threatening events such as myocardial infarction or stroke. Current concepts consider a rupture (resp. erosion) of “unstable/vulnerable” atherosclerotic plaques as a primary cause leading to thrombus formation and subsequent occlusion of the artery lumen finally triggering an acute clinical event. We and others described SR-B1-/-ApoE-R61h/h mice mimicking clinical coronary heart disease in all major aspects: from coronary atherosclerosis through vulnerable plaque ruptures leading to thrombus formation/coronary artery occlusion, finally resulting in myocardial infarction/ischemia. SR-B1-/-ApoE-R61h/h mouse provides a valuable model to study vulnerable/occlusive plaques, to evaluate bioactive compounds as well as new anti-inflammatory and “anti-rupture” drugs, and to test new technologies in experimental cardiovascular medicine. This review summarizes and discuss our knowledge about SR-B1-/-ApoE-R61h/h mouse model based on recent publications and experimental observations from the lab. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10557-023-07475-8. |
format | Online Article Text |
id | pubmed-10240136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-102401362023-06-06 SR-B1-/-ApoE-R61h/h Mice Mimic Human Coronary Heart Disease Staršíchová, Andrea Cardiovasc Drugs Ther Review Article Cardiovascular diseases are the leading cause of death in the modern world. Atherosclerosis underlies the majority of these pathologies and may result in sudden life-threatening events such as myocardial infarction or stroke. Current concepts consider a rupture (resp. erosion) of “unstable/vulnerable” atherosclerotic plaques as a primary cause leading to thrombus formation and subsequent occlusion of the artery lumen finally triggering an acute clinical event. We and others described SR-B1-/-ApoE-R61h/h mice mimicking clinical coronary heart disease in all major aspects: from coronary atherosclerosis through vulnerable plaque ruptures leading to thrombus formation/coronary artery occlusion, finally resulting in myocardial infarction/ischemia. SR-B1-/-ApoE-R61h/h mouse provides a valuable model to study vulnerable/occlusive plaques, to evaluate bioactive compounds as well as new anti-inflammatory and “anti-rupture” drugs, and to test new technologies in experimental cardiovascular medicine. This review summarizes and discuss our knowledge about SR-B1-/-ApoE-R61h/h mouse model based on recent publications and experimental observations from the lab. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10557-023-07475-8. Springer US 2023-06-05 /pmc/articles/PMC10240136/ /pubmed/37273155 http://dx.doi.org/10.1007/s10557-023-07475-8 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Staršíchová, Andrea SR-B1-/-ApoE-R61h/h Mice Mimic Human Coronary Heart Disease |
title | SR-B1-/-ApoE-R61h/h Mice Mimic Human Coronary Heart Disease |
title_full | SR-B1-/-ApoE-R61h/h Mice Mimic Human Coronary Heart Disease |
title_fullStr | SR-B1-/-ApoE-R61h/h Mice Mimic Human Coronary Heart Disease |
title_full_unstemmed | SR-B1-/-ApoE-R61h/h Mice Mimic Human Coronary Heart Disease |
title_short | SR-B1-/-ApoE-R61h/h Mice Mimic Human Coronary Heart Disease |
title_sort | sr-b1-/-apoe-r61h/h mice mimic human coronary heart disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240136/ https://www.ncbi.nlm.nih.gov/pubmed/37273155 http://dx.doi.org/10.1007/s10557-023-07475-8 |
work_keys_str_mv | AT starsichovaandrea srb1apoer61hhmicemimichumancoronaryheartdisease |