Inflammatory Fabry Cardiomyopathy Demonstrated Using Simultaneous [(18)F]-FDG PET-CMR

Using hybridized [(18)F]-fluorodeoxyglucose positron emission tomography with cardiac magnetic resonance, we identify active myocardial inflammation and demonstrate its relationship with late gadolinium enhancement, in Fabry disease. We demonstrate that late gadolinium enhancement represents, at lea...

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Detalles Bibliográficos
Autores principales: Orsborne, Christopher, Anton-Rodrigez, Jose M., Sherratt, Neal, Watkins, Amy, Lohezic, Maelene, Clark, David, Lloyd, William, Naish, Josephine H., Woolfson, Peter, Reid, Anna B., Schmitt, Matthias, Muthu, Sivakumar, Arumugam, Parthiban, Jovanovic, Ana, Miller, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Mini-Focus Issue: Structural Heart
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240277/
https://www.ncbi.nlm.nih.gov/pubmed/37283843
http://dx.doi.org/10.1016/j.jaccas.2023.101863
Descripción
Sumario:Using hybridized [(18)F]-fluorodeoxyglucose positron emission tomography with cardiac magnetic resonance, we identify active myocardial inflammation and demonstrate its relationship with late gadolinium enhancement, in Fabry disease. We demonstrate that late gadolinium enhancement represents, at least in part, active myocardial inflammation and identify an early inflammatory phenotype that may represent a therapeutic window before irreversible tissue injury and adaptation occur. (Level of Difficulty: Intermediate.)

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