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Regulatory mechanisms of macrophage polarization in adipose tissue

In adipose tissue, macrophages are the most abundant immune cells with high heterogeneity and plasticity. Depending on environmental cues and molecular mediators, adipose tissue macrophages (ATMs) can be polarized into pro- or anti-inflammatory cells. In the state of obesity, ATMs switch from the M2...

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Autores principales: Pan, Dun, Li, Guo, Jiang, Chunlin, Hu, Jinfeng, Hu, Xiangming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240406/
https://www.ncbi.nlm.nih.gov/pubmed/37283763
http://dx.doi.org/10.3389/fimmu.2023.1149366
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author Pan, Dun
Li, Guo
Jiang, Chunlin
Hu, Jinfeng
Hu, Xiangming
author_facet Pan, Dun
Li, Guo
Jiang, Chunlin
Hu, Jinfeng
Hu, Xiangming
author_sort Pan, Dun
collection PubMed
description In adipose tissue, macrophages are the most abundant immune cells with high heterogeneity and plasticity. Depending on environmental cues and molecular mediators, adipose tissue macrophages (ATMs) can be polarized into pro- or anti-inflammatory cells. In the state of obesity, ATMs switch from the M2 polarized state to the M1 state, which contributes to chronic inflammation, thereby promoting the pathogenic progression of obesity and other metabolic diseases. Recent studies show that multiple ATM subpopulations cluster separately from the M1 or M2 polarized state. Various factors are related to ATM polarization, including cytokines, hormones, metabolites and transcription factors. Here, we discuss our current understanding of the potential regulatory mechanisms underlying ATM polarization induced by autocrine and paracrine factors. A better understanding of how ATMs polarize may provide new therapeutic strategies for obesity-related diseases.
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spelling pubmed-102404062023-06-06 Regulatory mechanisms of macrophage polarization in adipose tissue Pan, Dun Li, Guo Jiang, Chunlin Hu, Jinfeng Hu, Xiangming Front Immunol Immunology In adipose tissue, macrophages are the most abundant immune cells with high heterogeneity and plasticity. Depending on environmental cues and molecular mediators, adipose tissue macrophages (ATMs) can be polarized into pro- or anti-inflammatory cells. In the state of obesity, ATMs switch from the M2 polarized state to the M1 state, which contributes to chronic inflammation, thereby promoting the pathogenic progression of obesity and other metabolic diseases. Recent studies show that multiple ATM subpopulations cluster separately from the M1 or M2 polarized state. Various factors are related to ATM polarization, including cytokines, hormones, metabolites and transcription factors. Here, we discuss our current understanding of the potential regulatory mechanisms underlying ATM polarization induced by autocrine and paracrine factors. A better understanding of how ATMs polarize may provide new therapeutic strategies for obesity-related diseases. Frontiers Media S.A. 2023-05-22 /pmc/articles/PMC10240406/ /pubmed/37283763 http://dx.doi.org/10.3389/fimmu.2023.1149366 Text en Copyright © 2023 Pan, Li, Jiang, Hu and Hu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Pan, Dun
Li, Guo
Jiang, Chunlin
Hu, Jinfeng
Hu, Xiangming
Regulatory mechanisms of macrophage polarization in adipose tissue
title Regulatory mechanisms of macrophage polarization in adipose tissue
title_full Regulatory mechanisms of macrophage polarization in adipose tissue
title_fullStr Regulatory mechanisms of macrophage polarization in adipose tissue
title_full_unstemmed Regulatory mechanisms of macrophage polarization in adipose tissue
title_short Regulatory mechanisms of macrophage polarization in adipose tissue
title_sort regulatory mechanisms of macrophage polarization in adipose tissue
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240406/
https://www.ncbi.nlm.nih.gov/pubmed/37283763
http://dx.doi.org/10.3389/fimmu.2023.1149366
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