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Use of the Shizuoka Hip Fracture Prognostic Score (SHiPS) to Predict Long‐Term Mortality in Patients With Hip Fracture in Japan: A Cohort Study Using the Shizuoka Kokuho Database
Hip fractures are common in patients of advanced age and are associated with excess mortality. Rapid and accurate prediction of the prognosis using information that can be easily obtained before surgery would be advantageous to clinical management. We performed a population‐based retrospective cohor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241087/ https://www.ncbi.nlm.nih.gov/pubmed/37283648 http://dx.doi.org/10.1002/jbm4.10743 |
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author | Ohata, Emi Nakatani, Eiji Kaneda, Hideaki Fujimoto, Yoh Tanaka, Kiyoshi Takagi, Akira |
author_facet | Ohata, Emi Nakatani, Eiji Kaneda, Hideaki Fujimoto, Yoh Tanaka, Kiyoshi Takagi, Akira |
author_sort | Ohata, Emi |
collection | PubMed |
description | Hip fractures are common in patients of advanced age and are associated with excess mortality. Rapid and accurate prediction of the prognosis using information that can be easily obtained before surgery would be advantageous to clinical management. We performed a population‐based retrospective cohort study using an 8.5‐year Japanese claims database (April 2012–September 2020) to develop and validate a predictive model for long‐term mortality after hip fracture. The study included 43,529 patients (34,499 [79.3%] women) aged ≥65 years with first‐onset hip fracture. During the observation period, 43% of the patients died. Cox regression analysis identified the following prognostic predictors: sex, age, fracture site, nursing care certification, and several comorbidities (any malignancy, renal disease, congestive heart failure, chronic pulmonary disease, liver disease, metastatic solid tumor, and deficiency anemia). We then developed a scoring system called the Shizuoka Hip Fracture Prognostic Score (SHiPS); this system was established by scoring based on each hazard ratio and classifying the degree of mortality risk into four categories based on decision tree analysis. The area under the receiver operating characteristic (ROC) curve (AUC) (95% confidence interval [CI]) of 1‐year, 3‐year, and 5‐year mortality based on the SHiPS was 0.718 (95% CI, 0.706–0.729), 0.736 (95% CI, 0.728–0.745), and 0.758 (95% CI, 0.747–0.769), respectively, indicating good predictive performance of the SHiPS for as long as 5 years after fracture onset. Even when the SHiPS was individually applied to patients with or without surgery after fracture, the prediction performance by the AUC was >0.7. These results indicate that the SHiPS can predict long‐term mortality using preoperative information regardless of whether surgery is performed after hip fracture. |
format | Online Article Text |
id | pubmed-10241087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102410872023-06-06 Use of the Shizuoka Hip Fracture Prognostic Score (SHiPS) to Predict Long‐Term Mortality in Patients With Hip Fracture in Japan: A Cohort Study Using the Shizuoka Kokuho Database Ohata, Emi Nakatani, Eiji Kaneda, Hideaki Fujimoto, Yoh Tanaka, Kiyoshi Takagi, Akira JBMR Plus Research Articles Hip fractures are common in patients of advanced age and are associated with excess mortality. Rapid and accurate prediction of the prognosis using information that can be easily obtained before surgery would be advantageous to clinical management. We performed a population‐based retrospective cohort study using an 8.5‐year Japanese claims database (April 2012–September 2020) to develop and validate a predictive model for long‐term mortality after hip fracture. The study included 43,529 patients (34,499 [79.3%] women) aged ≥65 years with first‐onset hip fracture. During the observation period, 43% of the patients died. Cox regression analysis identified the following prognostic predictors: sex, age, fracture site, nursing care certification, and several comorbidities (any malignancy, renal disease, congestive heart failure, chronic pulmonary disease, liver disease, metastatic solid tumor, and deficiency anemia). We then developed a scoring system called the Shizuoka Hip Fracture Prognostic Score (SHiPS); this system was established by scoring based on each hazard ratio and classifying the degree of mortality risk into four categories based on decision tree analysis. The area under the receiver operating characteristic (ROC) curve (AUC) (95% confidence interval [CI]) of 1‐year, 3‐year, and 5‐year mortality based on the SHiPS was 0.718 (95% CI, 0.706–0.729), 0.736 (95% CI, 0.728–0.745), and 0.758 (95% CI, 0.747–0.769), respectively, indicating good predictive performance of the SHiPS for as long as 5 years after fracture onset. Even when the SHiPS was individually applied to patients with or without surgery after fracture, the prediction performance by the AUC was >0.7. These results indicate that the SHiPS can predict long‐term mortality using preoperative information regardless of whether surgery is performed after hip fracture. John Wiley & Sons, Inc. 2023-04-05 /pmc/articles/PMC10241087/ /pubmed/37283648 http://dx.doi.org/10.1002/jbm4.10743 Text en © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Ohata, Emi Nakatani, Eiji Kaneda, Hideaki Fujimoto, Yoh Tanaka, Kiyoshi Takagi, Akira Use of the Shizuoka Hip Fracture Prognostic Score (SHiPS) to Predict Long‐Term Mortality in Patients With Hip Fracture in Japan: A Cohort Study Using the Shizuoka Kokuho Database |
title | Use of the Shizuoka Hip Fracture Prognostic Score (SHiPS) to Predict Long‐Term Mortality in Patients With Hip Fracture in Japan: A Cohort Study Using the Shizuoka Kokuho Database |
title_full | Use of the Shizuoka Hip Fracture Prognostic Score (SHiPS) to Predict Long‐Term Mortality in Patients With Hip Fracture in Japan: A Cohort Study Using the Shizuoka Kokuho Database |
title_fullStr | Use of the Shizuoka Hip Fracture Prognostic Score (SHiPS) to Predict Long‐Term Mortality in Patients With Hip Fracture in Japan: A Cohort Study Using the Shizuoka Kokuho Database |
title_full_unstemmed | Use of the Shizuoka Hip Fracture Prognostic Score (SHiPS) to Predict Long‐Term Mortality in Patients With Hip Fracture in Japan: A Cohort Study Using the Shizuoka Kokuho Database |
title_short | Use of the Shizuoka Hip Fracture Prognostic Score (SHiPS) to Predict Long‐Term Mortality in Patients With Hip Fracture in Japan: A Cohort Study Using the Shizuoka Kokuho Database |
title_sort | use of the shizuoka hip fracture prognostic score (ships) to predict long‐term mortality in patients with hip fracture in japan: a cohort study using the shizuoka kokuho database |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241087/ https://www.ncbi.nlm.nih.gov/pubmed/37283648 http://dx.doi.org/10.1002/jbm4.10743 |
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