Synthesis of imidazo[1,2-a]pyridine-containing peptidomimetics by tandem of Groebke–Blackburn–Bienaymé and Ugi reactions

Peptidomimetics with a substituted imidazo[1,2-a]pyridine fragment were synthesized by a tandem of Groebke–Blackburn–Bienaymé and Ugi reactions. The target products contain substituted imidazo[1,2-a]pyridine and peptidomimetic moieties as pharmacophores with four diversity points introduced from rea...

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Autores principales: Kolomiiets, Oleksandr V, Tsygankov, Alexander V, Kornet, Maryna N, Brazhko, Aleksander A, Musatov, Vladimir I, Chebanov, Valentyn A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2023
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241102/
https://www.ncbi.nlm.nih.gov/pubmed/37284590
http://dx.doi.org/10.3762/bjoc.19.53
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author Kolomiiets, Oleksandr V
Tsygankov, Alexander V
Kornet, Maryna N
Brazhko, Aleksander A
Musatov, Vladimir I
Chebanov, Valentyn A
author_facet Kolomiiets, Oleksandr V
Tsygankov, Alexander V
Kornet, Maryna N
Brazhko, Aleksander A
Musatov, Vladimir I
Chebanov, Valentyn A
author_sort Kolomiiets, Oleksandr V
collection PubMed
description Peptidomimetics with a substituted imidazo[1,2-a]pyridine fragment were synthesized by a tandem of Groebke–Blackburn–Bienaymé and Ugi reactions. The target products contain substituted imidazo[1,2-a]pyridine and peptidomimetic moieties as pharmacophores with four diversity points introduced from readily available starting materials, including scaffold diversity. A small focused compound library of 20 Ugi products was prepared and screened for antibacterial activity.
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spelling pubmed-102411022023-06-06 Synthesis of imidazo[1,2-a]pyridine-containing peptidomimetics by tandem of Groebke–Blackburn–Bienaymé and Ugi reactions Kolomiiets, Oleksandr V Tsygankov, Alexander V Kornet, Maryna N Brazhko, Aleksander A Musatov, Vladimir I Chebanov, Valentyn A Beilstein J Org Chem Full Research Paper Peptidomimetics with a substituted imidazo[1,2-a]pyridine fragment were synthesized by a tandem of Groebke–Blackburn–Bienaymé and Ugi reactions. The target products contain substituted imidazo[1,2-a]pyridine and peptidomimetic moieties as pharmacophores with four diversity points introduced from readily available starting materials, including scaffold diversity. A small focused compound library of 20 Ugi products was prepared and screened for antibacterial activity. Beilstein-Institut 2023-05-26 /pmc/articles/PMC10241102/ /pubmed/37284590 http://dx.doi.org/10.3762/bjoc.19.53 Text en Copyright © 2023, Kolomiiets et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Full Research Paper
Kolomiiets, Oleksandr V
Tsygankov, Alexander V
Kornet, Maryna N
Brazhko, Aleksander A
Musatov, Vladimir I
Chebanov, Valentyn A
Synthesis of imidazo[1,2-a]pyridine-containing peptidomimetics by tandem of Groebke–Blackburn–Bienaymé and Ugi reactions
title Synthesis of imidazo[1,2-a]pyridine-containing peptidomimetics by tandem of Groebke–Blackburn–Bienaymé and Ugi reactions
title_full Synthesis of imidazo[1,2-a]pyridine-containing peptidomimetics by tandem of Groebke–Blackburn–Bienaymé and Ugi reactions
title_fullStr Synthesis of imidazo[1,2-a]pyridine-containing peptidomimetics by tandem of Groebke–Blackburn–Bienaymé and Ugi reactions
title_full_unstemmed Synthesis of imidazo[1,2-a]pyridine-containing peptidomimetics by tandem of Groebke–Blackburn–Bienaymé and Ugi reactions
title_short Synthesis of imidazo[1,2-a]pyridine-containing peptidomimetics by tandem of Groebke–Blackburn–Bienaymé and Ugi reactions
title_sort synthesis of imidazo[1,2-a]pyridine-containing peptidomimetics by tandem of groebke–blackburn–bienaymé and ugi reactions
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241102/
https://www.ncbi.nlm.nih.gov/pubmed/37284590
http://dx.doi.org/10.3762/bjoc.19.53
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