Real-world outcomes and toxicity of adjuvant chemotherapy in NSCLC: a single-center experience

AIM: Adjuvant chemotherapy in NSCLC is associated with modest benefits and significant toxicity. We sought to evaluate the toxicity of adjuvant chemotherapy and disease-specific outcomes in a real-world population. METHODS: We performed a retrospective analysis of patients undergoing adjuvant chemot...

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Detalles Bibliográficos
Autores principales: Cronin, Christopher, Iqbal, Shahid, Farooq, Abdul R, O'Dea, Pauline, Burke, Louise, O'Reilly, Seamus, O'Mahony, Deirdre, Power, Derek G, Bambury, Richard M, Collins, Dearbhaile C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241113/
https://www.ncbi.nlm.nih.gov/pubmed/37283858
http://dx.doi.org/10.2217/lmt-2022-0014
Descripción
Sumario:AIM: Adjuvant chemotherapy in NSCLC is associated with modest benefits and significant toxicity. We sought to evaluate the toxicity of adjuvant chemotherapy and disease-specific outcomes in a real-world population. METHODS: We performed a retrospective analysis of patients undergoing adjuvant chemotherapy for NSCLC in an Irish center over a 7-year period. We described treatment-associated toxicity, recurrence-free survival and overall survival. RESULTS: 62 patients underwent adjuvant chemotherapy. Treatment-associated hospitalisation occurred in 29% of patients. Relapse was recorded in 56% of patients and median recurrence-free survival was 27 months. CONCLUSION: High rates of disease recurrence and treatment-associated morbidity were observed in patients receiving adjuvant chemotherapy for NSCLC. Novel therapeutic strategies are required to improve outcomes in this population.

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