Extracellular vesicles enhance pulmonary transduction of stably associated adeno‐associated virus following intratracheal administration

Adeno‐associated virus (AAV) vector has shown multiple clinical breakthroughs, but its clinical implementation in inhaled gene therapy remains elusive due to difficulty in transducing lung airway cells. We demonstrate here AAV serotype 6 (AAV6) associated with extracellular vesicles (EVs) and secret...

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Detalles Bibliográficos
Autores principales: Kwak, Gijung, Gololobova, Olesia, Sharma, Neeraj, Caine, Colin, Mazur, Marina, Mulka, Kathleen, West, Natalie E., Solomon, George M., Cutting, Garry R., Witwer, Kenneth W., Rowe, Steven M., Paulaitis, Michael, Aslanidi, George, Suk, Jung Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241173/
https://www.ncbi.nlm.nih.gov/pubmed/37272896
http://dx.doi.org/10.1002/jev2.12324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241173/
https://www.ncbi.nlm.nih.gov/pubmed/37272896
http://dx.doi.org/10.1002/jev2.12324

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