Cargando…

Extracellular vesicles enhance pulmonary transduction of stably associated adeno‐associated virus following intratracheal administration

Adeno‐associated virus (AAV) vector has shown multiple clinical breakthroughs, but its clinical implementation in inhaled gene therapy remains elusive due to difficulty in transducing lung airway cells. We demonstrate here AAV serotype 6 (AAV6) associated with extracellular vesicles (EVs) and secret...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kwak, Gijung, Gololobova, Olesia, Sharma, Neeraj, Caine, Colin, Mazur, Marina, Mulka, Kathleen, West, Natalie E., Solomon, George M., Cutting, Garry R., Witwer, Kenneth W., Rowe, Steven M., Paulaitis, Michael, Aslanidi, George, Suk, Jung Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241173/ https://www.ncbi.nlm.nih.gov/pubmed/37272896 http://dx.doi.org/10.1002/jev2.12324

Ejemplares similares

High-Efficiency Transduction of Liver Cancer Cells by Recombinant Adeno-Associated Virus Serotype 3 Vectors
por: Ling, Chen, et al.
Publicado: (2011)

Modifiers of Adeno-Associated Virus-Mediated Gene Expression in Implication for Serotype-Universal Neutralizing Antibody Assay
por: Krotova, Karina, et al.
Publicado: (2020)

An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy
por: Duncan, Gregg A., et al.
Publicado: (2018)

Multiparametric domain insertional profiling of adeno-associated virus VP1
por: Hoffmann, Mareike D., et al.
Publicado: (2023)

The SUMOylation Pathway Restricts Gene Transduction by Adeno-Associated Viruses
por: Hölscher, Christina, et al.
Publicado: (2015)

Avian Adeno-Associated Viral Transduction of the Postembryonic Chicken Retina
por: Waldner, Derek M., et al.
Publicado: (2019)

Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors
por: Craig, Anthony T, et al.
Publicado: (2009)

Superior human hepatocyte transduction with Adeno-associated Virus Vector Serotype 7
por: Shao, Wenwei, et al.
Publicado: (2019)

Hyperthermia Enhances Adeno-Associated Virus Vector Transduction Efficiency in Melanoma Cells
por: Bieńkowska-Tokarczyk, Alicja, et al.
Publicado: (2023)

Rapid, widespread transduction of the murine myocardium using self-complementary Adeno-associated virus
por: Andino, Lourdes M, et al.
Publicado: (2007)

Recombinant Adeno-Associated Virus: Efficient Transduction of the Rat VMH and Clearance from Blood
por: van Gestel, Margriet A., et al.
Publicado: (2014)

Differential myofiber-type transduction preference of adeno-associated virus serotypes 6 and 9
por: Riaz, Muhammad, et al.
Publicado: (2015)

Improvement of Transduction Efficiency of Recombinant Adeno‐associated Virus Vector by Entrapment in Multilamellar Liposomes
por: Mizuno, Masaaki, et al.
Publicado: (1998)

Chimeric Capsid Proteins Impact Transduction Efficiency of Haploid Adeno-Associated Virus Vectors
por: Chai, Zheng, et al.
Publicado: (2019)

Transduction characteristics of alternative adeno-associated virus serotypes in the cat brain by intracisternal delivery
por: Hunter, Jacqueline E., et al.
Publicado: (2022)

The tyrosine capsid mutations on retrograde adeno-associated virus accelerates gene transduction efficiency
por: Nakahama, Ryota, et al.
Publicado: (2022)

Co-transduction of dual-adeno-associated virus vectors in the neonatal and adult mouse utricles
por: Chen, Zhong-Rui, et al.
Publicado: (2022)

Biophysical characterization of adeno-associated virus capsid through the viral transduction life cycle
por: Xiang, Yanqiao Shawn, et al.
Publicado: (2023)

Optimization of the Capsid of Recombinant Adeno-Associated Virus 2 (AAV2) Vectors: The Final Threshold?
por: Aslanidi, George V., et al.
Publicado: (2013)

miR-210 Expression Is Strongly Hypoxia-Induced in Anaplastic Thyroid Cancer Cell Lines and Is Associated with Extracellular Vesicles and Argonaute-2
por: Powell, Bonita H., et al.
Publicado: (2023)

Self-Complementary Adeno-Associated Virus Vectors Improve Transduction Efficiency of Corneal Endothelial Cells
por: Gruenert, Anja K., et al.
Publicado: (2016)

The Golgi Calcium ATPase Pump Plays an Essential Role in Adeno-associated Virus Trafficking and Transduction
por: Madigan, Victoria J., et al.
Publicado: (2020)

Self-complementarity in adeno-associated virus enhances transduction and gene expression in mouse cochlear tissues
por: Casey, Graham, et al.
Publicado: (2020)

Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tract: comparison of four promoters
por: Nieuwenhuis, Bart, et al.
Publicado: (2020)

Intra-tracheal delivery of AAV6 vectors results in sustained transduction in murine lungs without genomic integration
por: Colon-Cortes, Yanerys, et al.
Publicado: (2020)

Transduction of ovarian cancer cells: a recombinant adeno-associated viral vector compared to an adenoviral vector
por: Vermeij, J, et al.
Publicado: (2001)

A Novel Adeno-Associated Viral Variant for Efficient and Selective Intravitreal Transduction of Rat Müller Cells
por: Klimczak, Ryan R., et al.
Publicado: (2009)

P17-08. Transduction of human monocyte-derived dendritic cells by recombinant adeno-associated virus
por: Ussher, JE, et al.
Publicado: (2009)

Adeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain
por: Swain, G P, et al.
Publicado: (2014)

Adeno-associated-virus-mediated transduction of the mammary gland enables sustained production of recombinant proteins in milk
por: Wagner, Stefan, et al.
Publicado: (2015)

Transduction Patterns of Adeno-associated Viral Vectors in a Laser-Induced Choroidal Neovascularization Mouse Model
por: Lee, Si Hyung, et al.
Publicado: (2018)

Adeno-Associated Viral Vector 2 and 9 Transduction Is Enhanced in Streptozotocin-Induced Diabetic Mouse Retina
por: Lee, Si Hyung, et al.
Publicado: (2018)

Transduction of Adeno-Associated Virus Vectors Targeting Hair Cells and Supporting Cells in the Neonatal Mouse Cochlea
por: Gu, Xi, et al.
Publicado: (2019)

Cell-penetrating peptides enhance the transduction of adeno-associated virus serotype 9 in the central nervous system
por: Meng, Yuan, et al.
Publicado: (2021)

Pre-retinal delivery of recombinant adeno-associated virus vector significantly improves retinal transduction efficiency
por: Zhang, Hanmeng, et al.
Publicado: (2021)

Cell-penetrating peptides enhance the transduction of adeno-associated virus serotype 9 in the central nervous system
por: Meng, Yuan, et al.
Publicado: (2022)

In situ transduction of cells in human corneal limbus using adeno-associated viruses: an ex vivo study
por: Son, Hyeck-Soo, et al.
Publicado: (2022)

Tumor antigen-loaded AAV vaccine drives protective immunity in a melanoma animal model
por: Krotova, Karina, et al.
Publicado: (2023)

Longitudinal characterization of circulating extracellular vesicles and small RNA during simian immunodeficiency virus infection and antiretroviral therapy
por: Huang, Yiyao, et al.
Publicado: (2023)

Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors
por: Ahmed, Bushra Y, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_d49bje7s37gnl3pj7sevdp11c1