A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer

Ribosomes in cancer cells accumulate numerous patient-specific structural and functional modifications that facilitate tumor progression by modifying protein translation. We have taken a unique synthetic chemistry approach to generate novel macrolides, Ribosome modulating agents (RMA), that are prop...

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Detalles Bibliográficos
Autores principales: Terzo, Esteban, Apte, Shruti A., Padhye, Simran, Rashed, Saleh, Austin, Wesley, Caponegro, Michael, Reddy, Anupama, Shi, Shuhao, Wang, Christy, Clark, Roger B., Sidransky, David, Modur, Vijay, Badarinarayana, Vasudeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241187/
https://www.ncbi.nlm.nih.gov/pubmed/37377612
http://dx.doi.org/10.1158/2767-9764.CRC-22-0469

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