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Using depth-enhanced diffuse correlation spectroscopy and near-infrared spectroscopy to isolate cerebral hemodynamics during transient hypotension
SIGNIFICANCE: Combining diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) permits simultaneous monitoring of multiple cerebral hemodynamic parameters related to cerebral autoregulation; however, interpreting these optical measurements can be confounded by signal contaminat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society of Photo-Optical Instrumentation Engineers
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241370/ https://www.ncbi.nlm.nih.gov/pubmed/37284246 http://dx.doi.org/10.1117/1.NPh.10.2.025013 |
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author | Shoemaker, Leena N. Milej, Daniel Mistry, Jigneshkumar St. Lawrence, Keith |
author_facet | Shoemaker, Leena N. Milej, Daniel Mistry, Jigneshkumar St. Lawrence, Keith |
author_sort | Shoemaker, Leena N. |
collection | PubMed |
description | SIGNIFICANCE: Combining diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) permits simultaneous monitoring of multiple cerebral hemodynamic parameters related to cerebral autoregulation; however, interpreting these optical measurements can be confounded by signal contamination from extracerebral tissue. AIM: We aimed to evaluate extracerebral signal contamination in NIRS/DCS data acquired during transient hypotension and assess suitable means of separating scalp and brain signals. APPROACH: A hybrid time-resolved NIRS/multidistance DCS system was used to simultaneously acquire cerebral oxygenation and blood flow data during transient orthostatic hypotension induced by rapid-onset lower body negative pressure (LBNP) in nine young, healthy adults. Changes in microvascular flow were verified against changes in middle cerebral artery velocity (MCAv) measured by transcranial Doppler ultrasound. RESULTS: LBNP significantly decreased arterial blood pressure ([Formula: see text]), scalp blood flow ([Formula: see text]), and scalp tissue oxygenation (all [Formula: see text] versus baseline). However, implementing depth-sensitive techniques for both DCS and time-resolved NIRS indicated that LBNP did not significantly alter microvascular cerebral blood flow and oxygenation relative to their baseline values (all [Formula: see text]). In agreement, there was no significant reduction in MCAv ([Formula: see text]; [Formula: see text]). CONCLUSION: Transient hypotension caused significantly larger blood flow and oxygenation changes in the extracerebral tissue compared to the brain. We demonstrate the importance of accounting for extracerebral signal contamination within optical measures of cerebral hemodynamics during physiological paradigms designed to test cerebral autoregulation. |
format | Online Article Text |
id | pubmed-10241370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Society of Photo-Optical Instrumentation Engineers |
record_format | MEDLINE/PubMed |
spelling | pubmed-102413702023-06-06 Using depth-enhanced diffuse correlation spectroscopy and near-infrared spectroscopy to isolate cerebral hemodynamics during transient hypotension Shoemaker, Leena N. Milej, Daniel Mistry, Jigneshkumar St. Lawrence, Keith Neurophotonics Research Papers SIGNIFICANCE: Combining diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) permits simultaneous monitoring of multiple cerebral hemodynamic parameters related to cerebral autoregulation; however, interpreting these optical measurements can be confounded by signal contamination from extracerebral tissue. AIM: We aimed to evaluate extracerebral signal contamination in NIRS/DCS data acquired during transient hypotension and assess suitable means of separating scalp and brain signals. APPROACH: A hybrid time-resolved NIRS/multidistance DCS system was used to simultaneously acquire cerebral oxygenation and blood flow data during transient orthostatic hypotension induced by rapid-onset lower body negative pressure (LBNP) in nine young, healthy adults. Changes in microvascular flow were verified against changes in middle cerebral artery velocity (MCAv) measured by transcranial Doppler ultrasound. RESULTS: LBNP significantly decreased arterial blood pressure ([Formula: see text]), scalp blood flow ([Formula: see text]), and scalp tissue oxygenation (all [Formula: see text] versus baseline). However, implementing depth-sensitive techniques for both DCS and time-resolved NIRS indicated that LBNP did not significantly alter microvascular cerebral blood flow and oxygenation relative to their baseline values (all [Formula: see text]). In agreement, there was no significant reduction in MCAv ([Formula: see text]; [Formula: see text]). CONCLUSION: Transient hypotension caused significantly larger blood flow and oxygenation changes in the extracerebral tissue compared to the brain. We demonstrate the importance of accounting for extracerebral signal contamination within optical measures of cerebral hemodynamics during physiological paradigms designed to test cerebral autoregulation. Society of Photo-Optical Instrumentation Engineers 2023-06-05 2023-04 /pmc/articles/PMC10241370/ /pubmed/37284246 http://dx.doi.org/10.1117/1.NPh.10.2.025013 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. |
spellingShingle | Research Papers Shoemaker, Leena N. Milej, Daniel Mistry, Jigneshkumar St. Lawrence, Keith Using depth-enhanced diffuse correlation spectroscopy and near-infrared spectroscopy to isolate cerebral hemodynamics during transient hypotension |
title | Using depth-enhanced diffuse correlation spectroscopy and near-infrared spectroscopy to isolate cerebral hemodynamics during transient hypotension |
title_full | Using depth-enhanced diffuse correlation spectroscopy and near-infrared spectroscopy to isolate cerebral hemodynamics during transient hypotension |
title_fullStr | Using depth-enhanced diffuse correlation spectroscopy and near-infrared spectroscopy to isolate cerebral hemodynamics during transient hypotension |
title_full_unstemmed | Using depth-enhanced diffuse correlation spectroscopy and near-infrared spectroscopy to isolate cerebral hemodynamics during transient hypotension |
title_short | Using depth-enhanced diffuse correlation spectroscopy and near-infrared spectroscopy to isolate cerebral hemodynamics during transient hypotension |
title_sort | using depth-enhanced diffuse correlation spectroscopy and near-infrared spectroscopy to isolate cerebral hemodynamics during transient hypotension |
topic | Research Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241370/ https://www.ncbi.nlm.nih.gov/pubmed/37284246 http://dx.doi.org/10.1117/1.NPh.10.2.025013 |
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