CpG 684: an effective adjuvant for the inactivated COVID-19 vaccine in mice

AIM: This study used CpG 684 as adjuvant of inactivated COVID-19 vaccine to detect a humoral and cellular immune response in mice. MATERIALS & METHODS: We used 10 and 20 µg CpG 684 as adjuvants of an inactivated COVID-19 vaccine to immunize mice. IgG, IgG1, IgG2a, IgG2b and IgM binding antibodie...

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Detalles Bibliográficos
Autores principales: Liu, Jiandong, Cang, Tianle, Jiang, Congli, Li, Kelei, Liu, Siyuan, Wang, Haixin, Wang, Meirong, Chen, Yan, Shao, Yan, Liu, Jiankai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241461/
http://dx.doi.org/10.2217/fvl-2022-0172
Descripción
Sumario:AIM: This study used CpG 684 as adjuvant of inactivated COVID-19 vaccine to detect a humoral and cellular immune response in mice. MATERIALS & METHODS: We used 10 and 20 µg CpG 684 as adjuvants of an inactivated COVID-19 vaccine to immunize mice. IgG, IgG1, IgG2a, IgG2b and IgM binding antibodies were detected in serum by ELISA. The IFN-γ cytokine was detected by ELISPOT. RESULTS: CpG 684 improved spike-specific IgG and IgM subtype binding antibodies and increased the neutralizing antibody titer against prototype, Delta and Beta strains. CpG 684 also improved cellular immune response. CONCLUSION: CpG 684 is an effective adjuvant for inactivated COVID-19 vaccine.

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