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Combined effect of physical exercise and hormone replacement therapy on cardiovascular and metabolic health in postmenopausal women: A systematic review and meta-analysis

The cardioprotective effect of postmenopausal hormone replacement therapy (HRT) has been demonstrated in several studies. Similarly, physical exercise has yielded positive results. However, the effects of their combination remain inconclusive. This review describes the combined effects of physical e...

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Autores principales: Sánchez-Delgado, J.C., Jácome-Hortúa, A.M., Uribe-Sarmiento, O.M., Philbois, S.V., Pereira, A.C., Rodrigues, K.P., Souza, H.C.D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241482/
https://www.ncbi.nlm.nih.gov/pubmed/37194832
http://dx.doi.org/10.1590/1414-431X2023e12241
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author Sánchez-Delgado, J.C.
Jácome-Hortúa, A.M.
Uribe-Sarmiento, O.M.
Philbois, S.V.
Pereira, A.C.
Rodrigues, K.P.
Souza, H.C.D.
author_facet Sánchez-Delgado, J.C.
Jácome-Hortúa, A.M.
Uribe-Sarmiento, O.M.
Philbois, S.V.
Pereira, A.C.
Rodrigues, K.P.
Souza, H.C.D.
author_sort Sánchez-Delgado, J.C.
collection PubMed
description The cardioprotective effect of postmenopausal hormone replacement therapy (HRT) has been demonstrated in several studies. Similarly, physical exercise has yielded positive results. However, the effects of their combination remain inconclusive. This review describes the combined effects of physical exercise and hormone therapy on cardiovascular and metabolic health in postmenopausal women. We searched the Scopus, Web of Science, PubMed, and Embase databases and included randomized controlled trials published up to December 2021 on the combined effects of physical exercise and hormone therapy on cardiovascular and metabolic health in postmenopausal women. We identified 148 articles, of which only seven met the inclusion criteria (386 participants; 91 [23%] HRT + exercise; 104 [27%] HRT; 103 [27%] exercise; 88 [23%] placebo). The combined treatment further decreased systolic blood pressure (SBP) compared to the isolated effect of aerobic training (AT) (mean difference [MD]=-1.69; 95% confidence interval [CI]=-2.65 to -0.72, n=73). Nevertheless, it attenuated the decrease in diastolic blood pressure (DBP) (MD=0.78; 95%CI: 0.22-1.35, n=73), and the increase in peak oxygen consumption (VO(2 peak)) promoted by exercise (AT + HRT=2.8±1.4 vs AT + placebo=5.8±3.4, P=0.02). The combination of AT and oral HRT improved SBP. However, AT alone seemed to have a better effect on physical fitness and DBP in postmenopausal women.
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spelling pubmed-102414822023-06-06 Combined effect of physical exercise and hormone replacement therapy on cardiovascular and metabolic health in postmenopausal women: A systematic review and meta-analysis Sánchez-Delgado, J.C. Jácome-Hortúa, A.M. Uribe-Sarmiento, O.M. Philbois, S.V. Pereira, A.C. Rodrigues, K.P. Souza, H.C.D. Braz J Med Biol Res Systematic Review The cardioprotective effect of postmenopausal hormone replacement therapy (HRT) has been demonstrated in several studies. Similarly, physical exercise has yielded positive results. However, the effects of their combination remain inconclusive. This review describes the combined effects of physical exercise and hormone therapy on cardiovascular and metabolic health in postmenopausal women. We searched the Scopus, Web of Science, PubMed, and Embase databases and included randomized controlled trials published up to December 2021 on the combined effects of physical exercise and hormone therapy on cardiovascular and metabolic health in postmenopausal women. We identified 148 articles, of which only seven met the inclusion criteria (386 participants; 91 [23%] HRT + exercise; 104 [27%] HRT; 103 [27%] exercise; 88 [23%] placebo). The combined treatment further decreased systolic blood pressure (SBP) compared to the isolated effect of aerobic training (AT) (mean difference [MD]=-1.69; 95% confidence interval [CI]=-2.65 to -0.72, n=73). Nevertheless, it attenuated the decrease in diastolic blood pressure (DBP) (MD=0.78; 95%CI: 0.22-1.35, n=73), and the increase in peak oxygen consumption (VO(2 peak)) promoted by exercise (AT + HRT=2.8±1.4 vs AT + placebo=5.8±3.4, P=0.02). The combination of AT and oral HRT improved SBP. However, AT alone seemed to have a better effect on physical fitness and DBP in postmenopausal women. Associação Brasileira de Divulgação Científica 2023-05-15 /pmc/articles/PMC10241482/ /pubmed/37194832 http://dx.doi.org/10.1590/1414-431X2023e12241 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Systematic Review
Sánchez-Delgado, J.C.
Jácome-Hortúa, A.M.
Uribe-Sarmiento, O.M.
Philbois, S.V.
Pereira, A.C.
Rodrigues, K.P.
Souza, H.C.D.
Combined effect of physical exercise and hormone replacement therapy on cardiovascular and metabolic health in postmenopausal women: A systematic review and meta-analysis
title Combined effect of physical exercise and hormone replacement therapy on cardiovascular and metabolic health in postmenopausal women: A systematic review and meta-analysis
title_full Combined effect of physical exercise and hormone replacement therapy on cardiovascular and metabolic health in postmenopausal women: A systematic review and meta-analysis
title_fullStr Combined effect of physical exercise and hormone replacement therapy on cardiovascular and metabolic health in postmenopausal women: A systematic review and meta-analysis
title_full_unstemmed Combined effect of physical exercise and hormone replacement therapy on cardiovascular and metabolic health in postmenopausal women: A systematic review and meta-analysis
title_short Combined effect of physical exercise and hormone replacement therapy on cardiovascular and metabolic health in postmenopausal women: A systematic review and meta-analysis
title_sort combined effect of physical exercise and hormone replacement therapy on cardiovascular and metabolic health in postmenopausal women: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241482/
https://www.ncbi.nlm.nih.gov/pubmed/37194832
http://dx.doi.org/10.1590/1414-431X2023e12241
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