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Impact of smoking on urologic cancers: a snapshot of current evidence

PURPOSE: The purpose of this paper is to present evidence regarding the associations between smoking and the following urologic cancers: prostate, bladder, renal, and upper tract urothelial cancer (UTUC). METHODS: This is a narrative review. PubMed was queried for evidence-based analyses and trials...

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Autores principales: Kumar, Raj, Matulewicz, Richard, Mari, Andrea, Moschini, Marco, Ghodoussipour, Saum, Pradere, Benjamin, Rink, Michael, Autorino, Riccardo, Desai, Mihir M., Gill, Inderbir, Cacciamani, Giovanni E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241723/
https://www.ncbi.nlm.nih.gov/pubmed/37093319
http://dx.doi.org/10.1007/s00345-023-04406-y
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author Kumar, Raj
Matulewicz, Richard
Mari, Andrea
Moschini, Marco
Ghodoussipour, Saum
Pradere, Benjamin
Rink, Michael
Autorino, Riccardo
Desai, Mihir M.
Gill, Inderbir
Cacciamani, Giovanni E.
author_facet Kumar, Raj
Matulewicz, Richard
Mari, Andrea
Moschini, Marco
Ghodoussipour, Saum
Pradere, Benjamin
Rink, Michael
Autorino, Riccardo
Desai, Mihir M.
Gill, Inderbir
Cacciamani, Giovanni E.
author_sort Kumar, Raj
collection PubMed
description PURPOSE: The purpose of this paper is to present evidence regarding the associations between smoking and the following urologic cancers: prostate, bladder, renal, and upper tract urothelial cancer (UTUC). METHODS: This is a narrative review. PubMed was queried for evidence-based analyses and trials regarding the associations between smoking and prostate, bladder, renal, and UTUC tumors from inception to September 1, 2022. Emphasis was placed on articles referenced in national guidelines and protocols. RESULTS: Prostate—multiple studies associate smoking with higher Gleason score, higher tumor stage, and extracapsular invasion. Though smoking has not yet been linked to tumorigenesis, there is evidence that it plays a role in biochemical recurrence and cancer-specific mortality. Bladder—smoking is strongly associated with bladder cancer, likely due to DNA damage from the release of carcinogenic compounds. Additionally, smoking has been linked to increased cancer-specific mortality and higher risk of tumor recurrence. Renal—smoking tobacco has been associated with tumorigenesis, higher tumor grade and stage, poorer mortality rates, and a greater risk of tumor recurrence. UTUC—tumorigenesis has been associated with smoking tobacco. Additionally, more advanced disease, higher stage, lymph node metastases, poorer survival outcomes, and tumor recurrence have been linked to smoking. CONCLUSION: Smoking has been shown to significantly affect most urologic cancers and has been associated with more aggressive disease, poorer outcomes, and tumor recurrence. The role of smoking cessation is still unclear, but appears to provide some protective effect. Urologists have an opportunity to engage in primary prevention by encouraging cessation practices.
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spelling pubmed-102417232023-06-07 Impact of smoking on urologic cancers: a snapshot of current evidence Kumar, Raj Matulewicz, Richard Mari, Andrea Moschini, Marco Ghodoussipour, Saum Pradere, Benjamin Rink, Michael Autorino, Riccardo Desai, Mihir M. Gill, Inderbir Cacciamani, Giovanni E. World J Urol Original Article PURPOSE: The purpose of this paper is to present evidence regarding the associations between smoking and the following urologic cancers: prostate, bladder, renal, and upper tract urothelial cancer (UTUC). METHODS: This is a narrative review. PubMed was queried for evidence-based analyses and trials regarding the associations between smoking and prostate, bladder, renal, and UTUC tumors from inception to September 1, 2022. Emphasis was placed on articles referenced in national guidelines and protocols. RESULTS: Prostate—multiple studies associate smoking with higher Gleason score, higher tumor stage, and extracapsular invasion. Though smoking has not yet been linked to tumorigenesis, there is evidence that it plays a role in biochemical recurrence and cancer-specific mortality. Bladder—smoking is strongly associated with bladder cancer, likely due to DNA damage from the release of carcinogenic compounds. Additionally, smoking has been linked to increased cancer-specific mortality and higher risk of tumor recurrence. Renal—smoking tobacco has been associated with tumorigenesis, higher tumor grade and stage, poorer mortality rates, and a greater risk of tumor recurrence. UTUC—tumorigenesis has been associated with smoking tobacco. Additionally, more advanced disease, higher stage, lymph node metastases, poorer survival outcomes, and tumor recurrence have been linked to smoking. CONCLUSION: Smoking has been shown to significantly affect most urologic cancers and has been associated with more aggressive disease, poorer outcomes, and tumor recurrence. The role of smoking cessation is still unclear, but appears to provide some protective effect. Urologists have an opportunity to engage in primary prevention by encouraging cessation practices. Springer Berlin Heidelberg 2023-04-24 2023 /pmc/articles/PMC10241723/ /pubmed/37093319 http://dx.doi.org/10.1007/s00345-023-04406-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Kumar, Raj
Matulewicz, Richard
Mari, Andrea
Moschini, Marco
Ghodoussipour, Saum
Pradere, Benjamin
Rink, Michael
Autorino, Riccardo
Desai, Mihir M.
Gill, Inderbir
Cacciamani, Giovanni E.
Impact of smoking on urologic cancers: a snapshot of current evidence
title Impact of smoking on urologic cancers: a snapshot of current evidence
title_full Impact of smoking on urologic cancers: a snapshot of current evidence
title_fullStr Impact of smoking on urologic cancers: a snapshot of current evidence
title_full_unstemmed Impact of smoking on urologic cancers: a snapshot of current evidence
title_short Impact of smoking on urologic cancers: a snapshot of current evidence
title_sort impact of smoking on urologic cancers: a snapshot of current evidence
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241723/
https://www.ncbi.nlm.nih.gov/pubmed/37093319
http://dx.doi.org/10.1007/s00345-023-04406-y
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