Activation-inducible CAR expression enables precise control over engineered CAR T cell function

CAR T cell therapy is a rapidly growing area of oncological treatments having a potential of becoming standard care for multiple indications. Coincidently, CRISPR/Cas gene-editing technology is entering next-generation CAR T cell product manufacturing with the promise of more precise and more contro...

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Detalles Bibliográficos
Autores principales: Fraessle, Simon P., Tschulik, Claudia, Effenberger, Manuel, Cletiu, Vlad, Gerget, Maria, Schober, Kilian, Busch, Dirk H., Germeroth, Lothar, Stemberger, Christian, Poltorak, Mateusz P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241805/
https://www.ncbi.nlm.nih.gov/pubmed/37277433
http://dx.doi.org/10.1038/s42003-023-04978-w

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