Cargando…

Immunological and prognostic significance of tumour necrosis in colorectal cancer

BACKGROUND: Colorectal cancer (CRC) causes the second most cancer deaths worldwide, but the disease course varies according to tumour characteristics and immunological factors. Our objective was to examine the associations of tumour necrosis with tumour characteristics, immune cell infiltrates, seru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kastinen, Meeri, Sirniö, Päivi, Elomaa, Hanna, Ahtiainen, Maarit, Väyrynen, Sara A., Herzig, Karl-Heinz, Meriläinen, Sanna, Aro, Raila, Häivälä, Reetta, Rautio, Tero, Saarnio, Juha, Wirta, Erkki-Ville, Helminen, Olli, Seppälä, Toni T., Kuopio, Teijo, Böhm, Jan, Tuomisto, Anne, Mecklin, Jukka-Pekka, Mäkinen, Markus J., Väyrynen, Juha P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241859/ https://www.ncbi.nlm.nih.gov/pubmed/37031328 http://dx.doi.org/10.1038/s41416-023-02258-2

Ejemplares similares

Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases
por: Ahtiainen, Maarit, et al.
Publicado: (2021)

Sarcopenia and Myosteatosis Are Associated with Neutrophil to Lymphocyte Ratio but Not Glasgow Prognostic Score in Colorectal Cancer Patients
por: Aro, Raila, et al.
Publicado: (2022)

Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer
por: Elomaa, Hanna, et al.
Publicado: (2022)

Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer
por: Elomaa, Hanna, et al.
Publicado: (2023)

Immunoscore in mismatch repair‐proficient and ‐deficient colon cancer
por: Wirta, Erkki‐Ville, et al.
Publicado: (2017)

Tertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer
por: Karjula, Topias, et al.
Publicado: (2023)

CD3(+) and CD8(+) T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer
por: Karjula, Topias, et al.
Publicado: (2022)

Perioperative oral nutritional support for patients diagnosed with primary colon adenocarcinoma undergoing radical surgical procedures -Peri-Nutri Trial: study protocol for a randomized controlled trial
por: Aro, Raila, et al.
Publicado: (2022)

Immunophenotype based on inflammatory cells, PD-1/PD-L1 signalling pathway and M2 macrophages predicts survival in gastric cancer
por: Junttila, Anna, et al.
Publicado: (2020)

Impact of Age and Comorbidity on Multimodal Management and Survival from Colorectal Cancer: A Population-Based Study
por: Kellokumpu, Ilmo, et al.
Publicado: (2021)

A prognostic score based on B cell and plasma cell densities compared to T cell densities in colorectal cancer
por: Karjalainen, Henna, et al.
Publicado: (2023)

Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer
por: Väyrynen, Juha P., et al.
Publicado: (2019)

Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer
por: Sirniö, Päivi, et al.
Publicado: (2017)

Alterations in serum amino-acid profile in the progression of colorectal cancer: associations with systemic inflammation, tumour stage and patient survival
por: Sirniö, Päivi, et al.
Publicado: (2018)

Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance
por: Tuomisto, Anne E, et al.
Publicado: (2019)

Systemic inflammation is associated with circulating cell death released keratin 18 fragments in colorectal cancer
por: Sirniö, Päivi, et al.
Publicado: (2020)

Domain-specific transfer learning in the automated scoring of tumor-stroma ratio from histopathological images of colorectal cancer
por: Petäinen, Liisa, et al.
Publicado: (2023)

Immune cell score in pancreatic cancer—comparison of hotspot and whole-section techniques
por: Tahkola, Kyösti, et al.
Publicado: (2019)

Preoperative anemia in colorectal cancer: relationships with tumor characteristics, systemic inflammation, and survival
por: Väyrynen, Juha P., et al.
Publicado: (2018)

Serum enterolactone concentrations are low in colon but not in rectal cancer patients
por: Tuomisto, Anne, et al.
Publicado: (2019)

Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer
por: Tahkola, Kyösti, et al.
Publicado: (2021)

High-serum MMP-8 levels are associated with decreased survival and systemic inflammation in colorectal cancer
por: Sirniö, Päivi, et al.
Publicado: (2018)

Clinical impact and network of determinants of tumour necrosis in colorectal cancer
por: Väyrynen, Sara A, et al.
Publicado: (2016)

A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies
por: Härkönen, Jouni, et al.
Publicado: (2023)

Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions
por: Wirta, Erkki-Ville, et al.
Publicado: (2020)

Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases: a population‐based study
por: Väyrynen, V., et al.
Publicado: (2020)

Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology
por: Väyrynen, Juha P., et al.
Publicado: (2016)

CD3(+), CD8(+), CD4(+) and FOXP3(+) T Cells in the Immune Microenvironment of Small Bowel Neuroendocrine Tumors
por: Hiltunen, Niko, et al.
Publicado: (2021)

Immunoprofiles and DNA Methylation of Inflammatory Marker Genes in Ulcerative Colitis-Associated Colorectal Tumorigenesis
por: Mäki-Nevala, Satu, et al.
Publicado: (2021)

Predictive value of p53, Ki67 and TLR5 in neoplastic progression of Barrett’s esophagus: a matched case–control study
por: Helminen, Olli, et al.
Publicado: (2022)

Does breast carcinoma belong to the Lynch syndrome tumor spectrum? – Somatic mutational profiles vs. ovarian and colorectal carcinomas
por: Porkka, Noora K., et al.
Publicado: (2020)

Systemic circulating microRNA landscape in Lynch syndrome
por: Sievänen, Tero, et al.
Publicado: (2022)

PD‐L1 and PD‐1 expression in thyroid follicular epithelial dysplasia: Hashimoto thyroiditis related atypia and potential papillary carcinoma precursor
por: Pakkanen, Emma, et al.
Publicado: (2022)

Putative anoikis resistant subpopulations are enriched in lymph node metastases and indicate adverse prognosis in colorectal carcinoma
por: Mattila, Taneli T., et al.
Publicado: (2022)

Results of intention-to-treat pulmonary metastasectomies in northern Finland revealing significant number of new lung primary carcinomas: time to move on from wedge resections?
por: Karjula, Topias, et al.
Publicado: (2023)

Monocarboxylate Transporters 1 and 4 and Prognosis in Small Bowel Neuroendocrine Tumors
por: Hiltunen, Niko, et al.
Publicado: (2022)

PD-1 and PD-L1 expression in pulmonary carcinoid tumors and their association to tumor spread
por: Vesterinen, Tiina, et al.
Publicado: (2019)

Thirty years of esophageal cancer surgery in Oulu University Hospital
por: Saviaro, Henna, et al.
Publicado: (2021)

Detailed analysis of inflammatory cell infiltration in colorectal cancer
por: Väyrynen, J P, et al.
Publicado: (2013)

Prognostic and predictive role of tumour-associated macrophages in HER2 positive breast cancer
por: Honkanen, Tiia J., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_dsk2gs2sqhgqijbkkr05rf36jl