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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase

The AAA+ ATPase p97/VCP together with different sets of substrate-delivery adapters and accessory cofactor proteins unfolds ubiquitinated substrates to facilitate degradation by the proteasome. The UBXD1 cofactor is connected to p97-associated multisystem proteinopathy but its biochemical function a...

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Detalles Bibliográficos
Autores principales:	Blueggel, Mike, Kroening, Alexander, Kracht, Matthias, van den Boom, Johannes, Dabisch, Matthias, Goehring, Anna, Kaschani, Farnusch, Kaiser, Markus, Bayer, Peter, Meyer, Hemmo, Beuck, Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241913/ https://www.ncbi.nlm.nih.gov/pubmed/37277335 http://dx.doi.org/10.1038/s41467-023-38604-4

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