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Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84

GPR84 is an orphan class A G protein-coupled receptor (GPCR) that is predominantly expressed in immune cells and plays important roles in inflammation, fibrosis, and metabolism. Here, we present cryo-electron microscopy (cryo-EM) structures of Gα(i) protein-coupled human GPR84 bound to a synthetic l...

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Detalles Bibliográficos
Autores principales:	Liu, Heng, Zhang, Qing, He, Xinheng, Jiang, Mengting, Wang, Siwei, Yan, Xiaoci, Cheng, Xi, Liu, Yang, Nan, Fa-Jun, Xu, H. Eric, Xie, Xin, Yin, Wanchao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241960/ https://www.ncbi.nlm.nih.gov/pubmed/37277332 http://dx.doi.org/10.1038/s41467-023-38985-6

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