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R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells

The PHD finger protein 6 (PHF6) mutations frequently occurred in hematopoietic malignancies. Although the R274X mutation in PHF6 (PHF6(R274X)) is one of the most common mutations identified in T cell acute lymphoblastic leukemia (T-ALL) and acute myeloid leukemia (AML) patients, the specific role of...

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Detalles Bibliográficos
Autores principales:	Lan, Yanjie, Yuan, Shengnan, Guo, Tengxiao, Hou, Shuaibing, Zhao, Fei, Yang, Wanzhu, Cao, Yigeng, Chu, Yajing, Jiang, Erlie, Yuan, Weiping, Wang, Xiaomin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241978/ https://www.ncbi.nlm.nih.gov/pubmed/37288345 http://dx.doi.org/10.1016/j.isci.2023.106817

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