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Azithromycin as a Possible Cause of Linear IgA Bullous Dermatosis

We present a rare case of linear IgA bullous dermatosis (LABD) in a 72-year-old male associated with the use of azithromycin. LABD presents as subepidermal blisters due to IgA antibodies targeting BPAG2, a component of hemidesmosomes. LABD is a rare diagnosis and may be idiopathic, associated with i...

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Detalles Bibliográficos
Autores principales: O’Connell, Cailin, Dacy, Nicole N, Brown, Shannon C, Lopez, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241994/
https://www.ncbi.nlm.nih.gov/pubmed/37288175
http://dx.doi.org/10.7759/cureus.38592
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author O’Connell, Cailin
Dacy, Nicole N
Brown, Shannon C
Lopez, Lisa
author_facet O’Connell, Cailin
Dacy, Nicole N
Brown, Shannon C
Lopez, Lisa
author_sort O’Connell, Cailin
collection PubMed
description We present a rare case of linear IgA bullous dermatosis (LABD) in a 72-year-old male associated with the use of azithromycin. LABD presents as subepidermal blisters due to IgA antibodies targeting BPAG2, a component of hemidesmosomes. LABD is a rare diagnosis and may be idiopathic, associated with illness, or medication-induced. The patient experienced a rash five days after completing a course of azithromycin for pneumonia. The diagnosis of LABD was confirmed with a biopsy and direct immunofluorescence. Lesions resolved over two weeks with an oral prednisone taper and topical clobetasol. This case represents just one of two previously reported cases in the literature of azithromycin-associated LABD. While LABD is well known to be induced by certain medications, this is only the second report of it being associated with the use of a macrolide. We propose that macrolides be included as a potential cause of medication-induced LABD.
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spelling pubmed-102419942023-06-07 Azithromycin as a Possible Cause of Linear IgA Bullous Dermatosis O’Connell, Cailin Dacy, Nicole N Brown, Shannon C Lopez, Lisa Cureus Dermatology We present a rare case of linear IgA bullous dermatosis (LABD) in a 72-year-old male associated with the use of azithromycin. LABD presents as subepidermal blisters due to IgA antibodies targeting BPAG2, a component of hemidesmosomes. LABD is a rare diagnosis and may be idiopathic, associated with illness, or medication-induced. The patient experienced a rash five days after completing a course of azithromycin for pneumonia. The diagnosis of LABD was confirmed with a biopsy and direct immunofluorescence. Lesions resolved over two weeks with an oral prednisone taper and topical clobetasol. This case represents just one of two previously reported cases in the literature of azithromycin-associated LABD. While LABD is well known to be induced by certain medications, this is only the second report of it being associated with the use of a macrolide. We propose that macrolides be included as a potential cause of medication-induced LABD. Cureus 2023-05-05 /pmc/articles/PMC10241994/ /pubmed/37288175 http://dx.doi.org/10.7759/cureus.38592 Text en Copyright © 2023, O’Connell et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
O’Connell, Cailin
Dacy, Nicole N
Brown, Shannon C
Lopez, Lisa
Azithromycin as a Possible Cause of Linear IgA Bullous Dermatosis
title Azithromycin as a Possible Cause of Linear IgA Bullous Dermatosis
title_full Azithromycin as a Possible Cause of Linear IgA Bullous Dermatosis
title_fullStr Azithromycin as a Possible Cause of Linear IgA Bullous Dermatosis
title_full_unstemmed Azithromycin as a Possible Cause of Linear IgA Bullous Dermatosis
title_short Azithromycin as a Possible Cause of Linear IgA Bullous Dermatosis
title_sort azithromycin as a possible cause of linear iga bullous dermatosis
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241994/
https://www.ncbi.nlm.nih.gov/pubmed/37288175
http://dx.doi.org/10.7759/cureus.38592
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