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Between Scylla and Charybdis: thrombosis in children with hemophilia
Thromboembolism is an infrequent complication in children with hemophilia that has been traditionally associated with the presence of a central venous access device. Novel rebalancing agents have shown promising results as prophylactic therapies to minimize the risk of bleeding but both thromboembol...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242037/ https://www.ncbi.nlm.nih.gov/pubmed/37287631 http://dx.doi.org/10.3389/fped.2023.1173549 |
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author | El Maamari, Jad Amid, Ali Pelland-Marcotte, Marie-Claude Tole, Soumitra |
author_facet | El Maamari, Jad Amid, Ali Pelland-Marcotte, Marie-Claude Tole, Soumitra |
author_sort | El Maamari, Jad |
collection | PubMed |
description | Thromboembolism is an infrequent complication in children with hemophilia that has been traditionally associated with the presence of a central venous access device. Novel rebalancing agents have shown promising results as prophylactic therapies to minimize the risk of bleeding but both thromboembolism and thrombotic microangiopathy have been reported as complications. The management of thrombosis in children with hemophilia is particularly challenging given the inherent risk of bleeding. In this paper, we present clinical vignettes to review the literature, highlight challenges, and describe our approach to managing thromboembolism in children with hemophilia. |
format | Online Article Text |
id | pubmed-10242037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102420372023-06-07 Between Scylla and Charybdis: thrombosis in children with hemophilia El Maamari, Jad Amid, Ali Pelland-Marcotte, Marie-Claude Tole, Soumitra Front Pediatr Pediatrics Thromboembolism is an infrequent complication in children with hemophilia that has been traditionally associated with the presence of a central venous access device. Novel rebalancing agents have shown promising results as prophylactic therapies to minimize the risk of bleeding but both thromboembolism and thrombotic microangiopathy have been reported as complications. The management of thrombosis in children with hemophilia is particularly challenging given the inherent risk of bleeding. In this paper, we present clinical vignettes to review the literature, highlight challenges, and describe our approach to managing thromboembolism in children with hemophilia. Frontiers Media S.A. 2023-05-23 /pmc/articles/PMC10242037/ /pubmed/37287631 http://dx.doi.org/10.3389/fped.2023.1173549 Text en © 2023 El Maamari, Amid, Pelland-Marcotte and Tole. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics El Maamari, Jad Amid, Ali Pelland-Marcotte, Marie-Claude Tole, Soumitra Between Scylla and Charybdis: thrombosis in children with hemophilia |
title | Between Scylla and Charybdis: thrombosis in children with hemophilia |
title_full | Between Scylla and Charybdis: thrombosis in children with hemophilia |
title_fullStr | Between Scylla and Charybdis: thrombosis in children with hemophilia |
title_full_unstemmed | Between Scylla and Charybdis: thrombosis in children with hemophilia |
title_short | Between Scylla and Charybdis: thrombosis in children with hemophilia |
title_sort | between scylla and charybdis: thrombosis in children with hemophilia |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242037/ https://www.ncbi.nlm.nih.gov/pubmed/37287631 http://dx.doi.org/10.3389/fped.2023.1173549 |
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