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Mechanical digit sensory stimulation: a randomized control trial on neurological and motor recovery in acute stroke
BACKGROUND: Mechanical digit sensory stimulation (MDSS) is a novel therapy designed to accelerate the recovery of upper limb (including hand) function in patients with hemiplegia following a stroke. The primary goal of this study was to investigate the effect of MDSS on patients with acute ischemic...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242038/ https://www.ncbi.nlm.nih.gov/pubmed/37287803 http://dx.doi.org/10.3389/fnins.2023.1134904 |
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author | Zhang, Shuting Yu, Yang Xu, Panpan Shen, Xianshan Fang, Chuanqin Wu, Xiaosan Qu, Ping Wu, Tingting Wang, Qing Mei Luo, Xun Hong, Yongfeng |
author_facet | Zhang, Shuting Yu, Yang Xu, Panpan Shen, Xianshan Fang, Chuanqin Wu, Xiaosan Qu, Ping Wu, Tingting Wang, Qing Mei Luo, Xun Hong, Yongfeng |
author_sort | Zhang, Shuting |
collection | PubMed |
description | BACKGROUND: Mechanical digit sensory stimulation (MDSS) is a novel therapy designed to accelerate the recovery of upper limb (including hand) function in patients with hemiplegia following a stroke. The primary goal of this study was to investigate the effect of MDSS on patients with acute ischemic stroke (AIS). METHODS: Sixty-one inpatients with AIS were randomly divided into conventional rehabilitation group (RG) and stimulation group (SG), and the latter group received MDSS therapy. A healthy group consisting of 30 healthy adults was also included. The interleukin-17A (IL-17A), vascular endothelial growth factor A (VEGF-A), and tumor necrosis factor-alpha (TNF-α) plasma levels were measured in all subjects. The neurological and motor functions of patients were evaluated using the National Institutes of Health Stroke Scale (NIHSS), Mini-Mental State Examination (MMSE), Fugel-Meyer Assessment (FMA), and Modified Barthel Index (MBI). RESULTS: After 12 days of intervention, the IL-17A, TNF-α, and NIHSS levels were significantly decreased, while the VEGF-A, MMSE, FMA, and MBI levels were significantly increased in both disease groups. No significant difference was observed between both disease groups after intervention. The levels of IL-17A and TNF-α were positively correlated with NIHSS but negatively correlated with MMSE, FMA, and MBI. The VEGF-A levels were negatively correlated with NIHSS but positively correlated with MMSE, FMA, and MBI. CONCLUSION: Both MDSS and conventional rehabilitation significantly reduce the production of IL-17A and TNF-α, increase the VEGF-A levels, and effectively improve cognition and motor function of hemiplegic patients with AIS, and the effects of MDSS and conventional rehabilitation are comparable. |
format | Online Article Text |
id | pubmed-10242038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102420382023-06-07 Mechanical digit sensory stimulation: a randomized control trial on neurological and motor recovery in acute stroke Zhang, Shuting Yu, Yang Xu, Panpan Shen, Xianshan Fang, Chuanqin Wu, Xiaosan Qu, Ping Wu, Tingting Wang, Qing Mei Luo, Xun Hong, Yongfeng Front Neurosci Neuroscience BACKGROUND: Mechanical digit sensory stimulation (MDSS) is a novel therapy designed to accelerate the recovery of upper limb (including hand) function in patients with hemiplegia following a stroke. The primary goal of this study was to investigate the effect of MDSS on patients with acute ischemic stroke (AIS). METHODS: Sixty-one inpatients with AIS were randomly divided into conventional rehabilitation group (RG) and stimulation group (SG), and the latter group received MDSS therapy. A healthy group consisting of 30 healthy adults was also included. The interleukin-17A (IL-17A), vascular endothelial growth factor A (VEGF-A), and tumor necrosis factor-alpha (TNF-α) plasma levels were measured in all subjects. The neurological and motor functions of patients were evaluated using the National Institutes of Health Stroke Scale (NIHSS), Mini-Mental State Examination (MMSE), Fugel-Meyer Assessment (FMA), and Modified Barthel Index (MBI). RESULTS: After 12 days of intervention, the IL-17A, TNF-α, and NIHSS levels were significantly decreased, while the VEGF-A, MMSE, FMA, and MBI levels were significantly increased in both disease groups. No significant difference was observed between both disease groups after intervention. The levels of IL-17A and TNF-α were positively correlated with NIHSS but negatively correlated with MMSE, FMA, and MBI. The VEGF-A levels were negatively correlated with NIHSS but positively correlated with MMSE, FMA, and MBI. CONCLUSION: Both MDSS and conventional rehabilitation significantly reduce the production of IL-17A and TNF-α, increase the VEGF-A levels, and effectively improve cognition and motor function of hemiplegic patients with AIS, and the effects of MDSS and conventional rehabilitation are comparable. Frontiers Media S.A. 2023-05-23 /pmc/articles/PMC10242038/ /pubmed/37287803 http://dx.doi.org/10.3389/fnins.2023.1134904 Text en Copyright © 2023 Zhang, Yu, Xu, Shen, Fang, Wu, Qu, Wu, Wang, Luo and Hong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhang, Shuting Yu, Yang Xu, Panpan Shen, Xianshan Fang, Chuanqin Wu, Xiaosan Qu, Ping Wu, Tingting Wang, Qing Mei Luo, Xun Hong, Yongfeng Mechanical digit sensory stimulation: a randomized control trial on neurological and motor recovery in acute stroke |
title | Mechanical digit sensory stimulation: a randomized control trial on neurological and motor recovery in acute stroke |
title_full | Mechanical digit sensory stimulation: a randomized control trial on neurological and motor recovery in acute stroke |
title_fullStr | Mechanical digit sensory stimulation: a randomized control trial on neurological and motor recovery in acute stroke |
title_full_unstemmed | Mechanical digit sensory stimulation: a randomized control trial on neurological and motor recovery in acute stroke |
title_short | Mechanical digit sensory stimulation: a randomized control trial on neurological and motor recovery in acute stroke |
title_sort | mechanical digit sensory stimulation: a randomized control trial on neurological and motor recovery in acute stroke |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242038/ https://www.ncbi.nlm.nih.gov/pubmed/37287803 http://dx.doi.org/10.3389/fnins.2023.1134904 |
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