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Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers

OBJECTIVE: To analyze the potential impact of sociodemographic, clinical and biological factors on the long-term cognitive outcome of patients who survived moderate and severe forms of COVID-19. METHODS: We assessed 710 adult participants (Mean age = 55 ± 14; 48.3% were female) 6 to 11 months after...

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Detalles Bibliográficos
Autores principales: Damiano, Rodolfo Furlan, Rocca, Cristiana Castanho de Almeida, Serafim, Antonio de Pádua, Loftis, Jennifer M., Talib, Leda Leme, Pan, Pedro Mário, Cunha-Neto, Edecio, Kalil, Jorge, de Castro, Gabriela Salim, Seelaender, Marilia, Guedes, Bruno F., Nagahashi Marie, Suely K., de Souza, Heraldo Possolo, Nitrini, Ricardo, Miguel, Euripedes Constantino, Busatto, Geraldo, Forlenza, Orestes V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242059/
https://www.ncbi.nlm.nih.gov/pubmed/37287969
http://dx.doi.org/10.3389/fimmu.2023.1174020
Descripción
Sumario:OBJECTIVE: To analyze the potential impact of sociodemographic, clinical and biological factors on the long-term cognitive outcome of patients who survived moderate and severe forms of COVID-19. METHODS: We assessed 710 adult participants (Mean age = 55 ± 14; 48.3% were female) 6 to 11 months after hospital discharge with a complete cognitive battery, as well as a psychiatric, clinical and laboratory evaluation. A large set of inferential statistical methods was used to predict potential variables associated with any long-term cognitive impairment, with a focus on a panel of 28 cytokines and other blood inflammatory and disease severity markers. RESULTS: Concerning the subjective assessment of cognitive performance, 36.1% reported a slightly poorer overall cognitive performance, and 14.6% reported being severely impacted, compared to their pre-COVID-19 status. Multivariate analysis found sex, age, ethnicity, education, comorbidity, frailty and physical activity associated with general cognition. A bivariate analysis found that G-CSF, IFN-alfa2, IL13, IL15, IL1.RA, EL1.alfa, IL45, IL5, IL6, IL7, TNF-Beta, VEGF, Follow-up C-Reactive Protein, and Follow-up D-Dimer were significantly (p<.05) associated with general cognition. However, a LASSO regression that included all follow-up variables, inflammatory markers and cytokines did not support these findings. CONCLUSION: Though we identified several sociodemographic characteristics that might protect against cognitive impairment following SARS-CoV-2 infection, our data do not support a prominent role for clinical status (both during acute and long-stage of COVID-19) or inflammatory background (also during acute and long-stage of COVID-19) to explain the cognitive deficits that can follow COVID-19 infection.