Transcriptomic signatures reveal a shift towards an anti-inflammatory gene expression profile but also the induction of type I and type II interferon signaling networks through aryl hydrocarbon receptor activation in murine macrophages

INTRODUCTION: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates a broad range of target genes involved in the xenobiotic response, cell cycle control and circadian rhythm. AhR is constitutively expressed in macrophages (Mϕ), acting as key regulator of cyto...

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Autores principales: Schmidt, Johannes R., Haupt, Janine, Riemschneider, Sina, Kämpf, Christoph, Löffler, Dennis, Blumert, Conny, Reiche, Kristin, Koehl, Ulrike, Kalkhof, Stefan, Lehmann, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242070/
https://www.ncbi.nlm.nih.gov/pubmed/37287978
http://dx.doi.org/10.3389/fimmu.2023.1156493

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