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High risk of osteoporosis and fracture following solid organ transplantation: a population-based study

BACKGROUND: Osteoporosis and fractures increase morbidity and mortality rates after solid organ transplantation (SOT), but few studies have analyzed the risk of osteoporosis and related fractures after SOT. In this retrospective cohort study, we investigated the risk of osteoporosis and fractures in...

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Autores principales: Chen, Hsin, Lai, Yung-Rung, Yang, Yih, Gau, Shuo-Yan, Huang, Cheng-Yang, Tsai, Tung-Han, Huang, Kuang-Hua, Lee, Chien-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242127/
https://www.ncbi.nlm.nih.gov/pubmed/37288297
http://dx.doi.org/10.3389/fendo.2023.1167574
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author Chen, Hsin
Lai, Yung-Rung
Yang, Yih
Gau, Shuo-Yan
Huang, Cheng-Yang
Tsai, Tung-Han
Huang, Kuang-Hua
Lee, Chien-Ying
author_facet Chen, Hsin
Lai, Yung-Rung
Yang, Yih
Gau, Shuo-Yan
Huang, Cheng-Yang
Tsai, Tung-Han
Huang, Kuang-Hua
Lee, Chien-Ying
author_sort Chen, Hsin
collection PubMed
description BACKGROUND: Osteoporosis and fractures increase morbidity and mortality rates after solid organ transplantation (SOT), but few studies have analyzed the risk of osteoporosis and related fractures after SOT. In this retrospective cohort study, we investigated the risk of osteoporosis and fractures in different SOT recipients. METHODS: This study was a retrospective cohort study using a nationally representative database in Taiwan. We collected the data of SOT recipients and used the propensity score matching method to obtain a comparison cohort. To reduce bias, we excluded patients who had been diagnosed with osteoporosis or fracture before inclusion. All participants were followed up until the date of diagnosis as having a pathological fracture, death, or the end of 2018, whichever occurred first. The Cox proportional hazards model was used to investigate the risk of osteoporosis and pathological fracture in SOT recipients. RESULTS: After adjustment for the aforementioned variables, SOT recipients were observed to have a higher risk of osteoporosis (hazard ratio (HR) = 1.46, 95% confidence interval (CI): 1.29–1.65) and fracture (HR: 1.19, 95% CI: 1.01–1.39) than the general individuals. Among the different SOT recipients, the highest risk of fractures was noted in heart or lung transplant recipients, with a HR of 4.62 (95% CI: 2.05–10.44). Among the age groups, patients aged >61 years had the highest HRs for osteoporosis (HR: 11.51; 95% CI, 9.10–14.56) and fracture (HR: 11.75, 95% CI: 8.97–15.40). CONCLUSION: SOT recipients had a higher risk of osteoporosis and related fractures than the general population, with the highest risks observed in patients receiving heart or lung transplants, older patients, and patients with CCI scores of >3.
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spelling pubmed-102421272023-06-07 High risk of osteoporosis and fracture following solid organ transplantation: a population-based study Chen, Hsin Lai, Yung-Rung Yang, Yih Gau, Shuo-Yan Huang, Cheng-Yang Tsai, Tung-Han Huang, Kuang-Hua Lee, Chien-Ying Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Osteoporosis and fractures increase morbidity and mortality rates after solid organ transplantation (SOT), but few studies have analyzed the risk of osteoporosis and related fractures after SOT. In this retrospective cohort study, we investigated the risk of osteoporosis and fractures in different SOT recipients. METHODS: This study was a retrospective cohort study using a nationally representative database in Taiwan. We collected the data of SOT recipients and used the propensity score matching method to obtain a comparison cohort. To reduce bias, we excluded patients who had been diagnosed with osteoporosis or fracture before inclusion. All participants were followed up until the date of diagnosis as having a pathological fracture, death, or the end of 2018, whichever occurred first. The Cox proportional hazards model was used to investigate the risk of osteoporosis and pathological fracture in SOT recipients. RESULTS: After adjustment for the aforementioned variables, SOT recipients were observed to have a higher risk of osteoporosis (hazard ratio (HR) = 1.46, 95% confidence interval (CI): 1.29–1.65) and fracture (HR: 1.19, 95% CI: 1.01–1.39) than the general individuals. Among the different SOT recipients, the highest risk of fractures was noted in heart or lung transplant recipients, with a HR of 4.62 (95% CI: 2.05–10.44). Among the age groups, patients aged >61 years had the highest HRs for osteoporosis (HR: 11.51; 95% CI, 9.10–14.56) and fracture (HR: 11.75, 95% CI: 8.97–15.40). CONCLUSION: SOT recipients had a higher risk of osteoporosis and related fractures than the general population, with the highest risks observed in patients receiving heart or lung transplants, older patients, and patients with CCI scores of >3. Frontiers Media S.A. 2023-05-23 /pmc/articles/PMC10242127/ /pubmed/37288297 http://dx.doi.org/10.3389/fendo.2023.1167574 Text en Copyright © 2023 Chen, Lai, Yang, Gau, Huang, Tsai, Huang and Lee https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Chen, Hsin
Lai, Yung-Rung
Yang, Yih
Gau, Shuo-Yan
Huang, Cheng-Yang
Tsai, Tung-Han
Huang, Kuang-Hua
Lee, Chien-Ying
High risk of osteoporosis and fracture following solid organ transplantation: a population-based study
title High risk of osteoporosis and fracture following solid organ transplantation: a population-based study
title_full High risk of osteoporosis and fracture following solid organ transplantation: a population-based study
title_fullStr High risk of osteoporosis and fracture following solid organ transplantation: a population-based study
title_full_unstemmed High risk of osteoporosis and fracture following solid organ transplantation: a population-based study
title_short High risk of osteoporosis and fracture following solid organ transplantation: a population-based study
title_sort high risk of osteoporosis and fracture following solid organ transplantation: a population-based study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242127/
https://www.ncbi.nlm.nih.gov/pubmed/37288297
http://dx.doi.org/10.3389/fendo.2023.1167574
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