Cargando…

cGAMP the travelling messenger

2’3’-cGAMP is a key molecule in the cGAS-STING pathway. This cyclic dinucleotide is produced by the cytosolic DNA sensor cGAS in response to the presence of aberrant dsDNA in the cytoplasm which is associated with microbial invasion or cellular damage. 2’3’-cGAMP acts as a second messenger and activ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blest, Henry T. W., Chauveau, Lise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242147/ https://www.ncbi.nlm.nih.gov/pubmed/37287967 http://dx.doi.org/10.3389/fimmu.2023.1150705

Ejemplares similares

Tumor-Derived cGAMP Regulates Activation of the Vasculature
por: Campisi, Marco, et al.
Publicado: (2020)

Self-assembled cGAMP-STINGΔTM signaling complex as a bioinspired platform for cGAMP delivery
por: He, Yanpu, et al.
Publicado: (2020)

The Signaling Pathway That cGAMP Riboswitches Found: Analysis and Application of Riboswitches to Study cGAMP Signaling in Geobacter sulfurreducens
por: Tan, Zhesen, et al.
Publicado: (2022)

Human SLC46A2 Is the Dominant cGAMP Importer in Extracellular cGAMP-Sensing Macrophages and Monocytes
por: Cordova, Anthony F., et al.
Publicado: (2021)

cGAMP: A tale of two signals
por: Kuriakose, Teneema, et al.
Publicado: (2017)

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
por: Li, Tiejun, et al.
Publicado: (2016)

cGAS Restricts PRRSV Replication by Sensing the mtDNA to Increase the cGAMP Activity
por: Liu, Xiao-Na, et al.
Publicado: (2022)

Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity
por: Chauveau, Lise, et al.
Publicado: (2021)

A noncanonical function of cGAMP in inflammasome priming and activation
por: Swanson, Karen V., et al.
Publicado: (2017)

Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation
por: Lai, Junzhong, et al.
Publicado: (2020)

cGAMP/Saponin Adjuvant Combination Improves Protective Response to Influenza Vaccination by Microneedle Patch in an Aged Mouse Model
por: Vassilieva, Elena V., et al.
Publicado: (2021)

Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger
por: Fatma, Shirin, et al.
Publicado: (2021)

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses
por: Pépin, Geneviève, et al.
Publicado: (2020)

Novel Poxin Stable cGAMP‐Derivatives Are Remarkable STING Agonists
por: Stazzoni, Samuele, et al.
Publicado: (2022)

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway
por: Wang, Songnan, et al.
Publicado: (2023)

Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer
por: Chen, Qing, et al.
Publicado: (2016)

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
por: Kato, Kazuki, et al.
Publicado: (2018)

Poxvirus cGAMP nucleases: Clues and mysteries from a stolen gene
por: Maluquer de Motes, Carlos
Publicado: (2021)

A Multi-Enzyme Cascade Reaction for the Production of 2′3′-cGAMP
por: Becker, Martin, et al.
Publicado: (2021)

Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis?
por: Elmanfi, Samira, et al.
Publicado: (2021)

ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling
por: Gentili, Matteo, et al.
Publicado: (2023)

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of non-hydrolyzable analogs
por: Li, Lingyin, et al.
Publicado: (2014)

Protocol for identification and validation of 2′3′-cGAMP-binding proteins by photoaffinity probes
por: Hou, Yingjie, et al.
Publicado: (2022)

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
por: Li, Tuo, et al.
Publicado: (2018)

The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism
por: Bai, Juli, et al.
Publicado: (2019)

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signaling
por: Eaglesham, James B., et al.
Publicado: (2019)

Sensing Cytosolic DNA Lowers Blood Pressure by Direct cGAMP-Dependent PKGI Activation
por: Su, Jie, et al.
Publicado: (2023)

Improving poxvirus-mediated antitumor immune responses by deleting viral cGAMP-specific nuclease
por: Riederer, Stephanie, et al.
Publicado: (2023)

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
por: Jønsson, K. L., et al.
Publicado: (2017)

Effects on Metabolism in Astrocytes Caused by cGAMP, Which Imitates the Initial Stage of Brain Metastasis
por: Okawa, Toya, et al.
Publicado: (2021)

An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP
por: Li, Xiaobo, et al.
Publicado: (2022)

ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling
por: Carozza, Jacqueline A., et al.
Publicado: (2022)

cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila
por: Slavik, Kailey M., et al.
Publicado: (2021)

cGAMP Promotes Germinal Center Formation and Production of IgA in Nasal-Associated Lymphoid Tissue
por: Takaki, Hiromi, et al.
Publicado: (2017)

Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency
por: Jütte, Bianca B., et al.
Publicado: (2021)

Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells
por: Wiser, Caroline, et al.
Publicado: (2020)

Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration
por: Hallberg, Zachary F, et al.
Publicado: (2019)

A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing
por: Wang, Pei-Hui, et al.
Publicado: (2018)

DNA-induced 2′3′-cGAMP enhances haplotype-specific human STING cleavage by dengue protease
por: Su, Chan-I, et al.
Publicado: (2020)

Activation of STING by cGAMP Regulates MDSCs to Suppress Tumor Metastasis via Reversing Epithelial-Mesenchymal Transition
por: Cheng, Hao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3f4p1c5hjeukao4bu55nfrbvcp