Toward a standard model for autophagosome biogenesis

Two papers in this issue resolve a long-standing obstacle to a “standard model” for autophagosome biogenesis in mammals. The first, Olivas et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202208088), uses biochemistry to confirm that the lipid scramblase ATG9A is a bona fide autophagosome com...

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Detalles Bibliográficos
Autores principales: Cook, Annan S.I., Hurley, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242208/
https://www.ncbi.nlm.nih.gov/pubmed/37273223
http://dx.doi.org/10.1083/jcb.202304011
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author Cook, Annan S.I.
Hurley, James H.
author_facet Cook, Annan S.I.
Hurley, James H.
author_sort Cook, Annan S.I.
collection PubMed
description Two papers in this issue resolve a long-standing obstacle to a “standard model” for autophagosome biogenesis in mammals. The first, Olivas et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202208088), uses biochemistry to confirm that the lipid scramblase ATG9A is a bona fide autophagosome component, while the second, Broadbent et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202210078), uses particle tracking to show that the dynamics of autophagy proteins are consistent with the concept.
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spelling pubmed-102422082023-12-05 Toward a standard model for autophagosome biogenesis Cook, Annan S.I. Hurley, James H. J Cell Biol Spotlight Two papers in this issue resolve a long-standing obstacle to a “standard model” for autophagosome biogenesis in mammals. The first, Olivas et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202208088), uses biochemistry to confirm that the lipid scramblase ATG9A is a bona fide autophagosome component, while the second, Broadbent et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202210078), uses particle tracking to show that the dynamics of autophagy proteins are consistent with the concept. Rockefeller University Press 2023-06-05 /pmc/articles/PMC10242208/ /pubmed/37273223 http://dx.doi.org/10.1083/jcb.202304011 Text en © 2023 Cook and Hurley https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Cook, Annan S.I.
Hurley, James H.
Toward a standard model for autophagosome biogenesis
title Toward a standard model for autophagosome biogenesis
title_full Toward a standard model for autophagosome biogenesis
title_fullStr Toward a standard model for autophagosome biogenesis
title_full_unstemmed Toward a standard model for autophagosome biogenesis
title_short Toward a standard model for autophagosome biogenesis
title_sort toward a standard model for autophagosome biogenesis
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242208/
https://www.ncbi.nlm.nih.gov/pubmed/37273223
http://dx.doi.org/10.1083/jcb.202304011
work_keys_str_mv AT cookannansi towardastandardmodelforautophagosomebiogenesis
AT hurleyjamesh towardastandardmodelforautophagosomebiogenesis

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