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Transcriptomic data in tumor‐adjacent normal tissues harbor prognostic information on multiple cancer types

BACKGROUND: In identifying prognostic markers in cancer, the roles of tumor‐adjacent normal tissues are often confined to drawing expression differences between tumor and normal tissues rather than being treated as the main targets of investigations. Thus, differential expression analysis between tu...

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Detalles Bibliográficos
Autores principales: Oh, Euiyoung, Lee, Hyunju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242347/
https://www.ncbi.nlm.nih.gov/pubmed/36999961
http://dx.doi.org/10.1002/cam4.5864
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author Oh, Euiyoung
Lee, Hyunju
author_facet Oh, Euiyoung
Lee, Hyunju
author_sort Oh, Euiyoung
collection PubMed
description BACKGROUND: In identifying prognostic markers in cancer, the roles of tumor‐adjacent normal tissues are often confined to drawing expression differences between tumor and normal tissues rather than being treated as the main targets of investigations. Thus, differential expression analysis between tumors and adjacent normal tissues is performed prior to prognostic analysis in previous studies. However, recent studies have suggested that the prognostic relevance of differentially expressed genes (DEGs) is insignificant for some cancers, contradicting conventional approaches METHODS: This study investigated the prognostic efficacy of transcriptomic data from tumors and adjacent normal tissues using The Cancer Genome Atlas dataset. Prognostic analysis using Cox regression models and survival prediction using machine‐learning models and feature selection methods were employed. RESULTS: The results revealed that for kidney, liver, and head and neck cancer, adjacent normal tissues harbored higher proportions of prognostic genes and exhibited better survival prediction performance than tumor tissues and DEGs in machine‐learning models. Furthermore, the application of a distance correlation‐based feature selection method to kidney and liver cancer using external datasets revealed that the selected genes for adjacent normal tissues exhibited higher prediction performance than those for tumor tissues. The study results suggest that the expression levels of genes in adjacent normal tissues are potential prognostic markers. The source code of this study is available at https://github.com/DMCB‐GIST/Survival_Normal.
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spelling pubmed-102423472023-06-07 Transcriptomic data in tumor‐adjacent normal tissues harbor prognostic information on multiple cancer types Oh, Euiyoung Lee, Hyunju Cancer Med Research Articles BACKGROUND: In identifying prognostic markers in cancer, the roles of tumor‐adjacent normal tissues are often confined to drawing expression differences between tumor and normal tissues rather than being treated as the main targets of investigations. Thus, differential expression analysis between tumors and adjacent normal tissues is performed prior to prognostic analysis in previous studies. However, recent studies have suggested that the prognostic relevance of differentially expressed genes (DEGs) is insignificant for some cancers, contradicting conventional approaches METHODS: This study investigated the prognostic efficacy of transcriptomic data from tumors and adjacent normal tissues using The Cancer Genome Atlas dataset. Prognostic analysis using Cox regression models and survival prediction using machine‐learning models and feature selection methods were employed. RESULTS: The results revealed that for kidney, liver, and head and neck cancer, adjacent normal tissues harbored higher proportions of prognostic genes and exhibited better survival prediction performance than tumor tissues and DEGs in machine‐learning models. Furthermore, the application of a distance correlation‐based feature selection method to kidney and liver cancer using external datasets revealed that the selected genes for adjacent normal tissues exhibited higher prediction performance than those for tumor tissues. The study results suggest that the expression levels of genes in adjacent normal tissues are potential prognostic markers. The source code of this study is available at https://github.com/DMCB‐GIST/Survival_Normal. John Wiley and Sons Inc. 2023-03-31 /pmc/articles/PMC10242347/ /pubmed/36999961 http://dx.doi.org/10.1002/cam4.5864 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Oh, Euiyoung
Lee, Hyunju
Transcriptomic data in tumor‐adjacent normal tissues harbor prognostic information on multiple cancer types
title Transcriptomic data in tumor‐adjacent normal tissues harbor prognostic information on multiple cancer types
title_full Transcriptomic data in tumor‐adjacent normal tissues harbor prognostic information on multiple cancer types
title_fullStr Transcriptomic data in tumor‐adjacent normal tissues harbor prognostic information on multiple cancer types
title_full_unstemmed Transcriptomic data in tumor‐adjacent normal tissues harbor prognostic information on multiple cancer types
title_short Transcriptomic data in tumor‐adjacent normal tissues harbor prognostic information on multiple cancer types
title_sort transcriptomic data in tumor‐adjacent normal tissues harbor prognostic information on multiple cancer types
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242347/
https://www.ncbi.nlm.nih.gov/pubmed/36999961
http://dx.doi.org/10.1002/cam4.5864
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