Alectinib for treating patients with metastatic ALK-positive NSCLC: systematic review and network metanalysis

AIM: To compare the efficacy and safety of alectinib with other ALK inhibitors in treating patients with metastatic or locally advanced ALK-positive NSCLC. METHODS: A systematic literature review was conducted up to November 2021. Network meta-analyses were performed using the frequentist method (ra...

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Detalles Bibliográficos
Autores principales: Samacá-Samacá, Daniel, Prieto-Pinto, Laura, Peréz, Andrés Yepes, Valderrama, Carolina, Hernández, Fabián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2023
Materias:
Meta-Analysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242442/
https://www.ncbi.nlm.nih.gov/pubmed/37287941
http://dx.doi.org/10.2217/lmt-2022-0018
Descripción
Sumario:AIM: To compare the efficacy and safety of alectinib with other ALK inhibitors in treating patients with metastatic or locally advanced ALK-positive NSCLC. METHODS: A systematic literature review was conducted up to November 2021. Network meta-analyses were performed using the frequentist method (random effects). GRADE evidence profile was conducted. RESULTS: 13 RCTs were selected. For overall survival, alectinib was found to reduce the risk of death compared with crizotinib. In progression-free survival, alectinib reduced the risk of death or progression compared with crizotinib and ceritinib. Subgroup analysis by brain metastasis at baseline showed the superiority of alectinib over crizotinib and a similar effect compared with second-and third-generation inhibitors. Alectinib showed a good safety profile compared with the other ALK inhibitors.

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