Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies

Lassa fever is an acute hemorrhagic fever caused by the zoonotic Lassa virus (LASV). The LASV glycoprotein complex (GPC) mediates viral entry and is the sole target for neutralizing antibodies. Immunogen design is complicated by the metastable nature of recombinant GPCs and the antigenic differences...

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Detalles Bibliográficos
Autores principales: Perrett, Hailee R., Brouwer, Philip J.M., Hurtado, Jonathan, Newby, Maddy L., Liu, Lin, Müller-Kräuter, Helena, Müller Aguirre, Sarah, Burger, Judith A., Bouhuijs, Joey H., Gibson, Grace, Messmer, Terrence, Schieffelin, John S., Antanasijevic, Aleksandar, Boons, Geert-Jan, Strecker, Thomas, Crispin, Max, Sanders, Rogier W., Briney, Bryan, Ward, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242449/
https://www.ncbi.nlm.nih.gov/pubmed/37209096
http://dx.doi.org/10.1016/j.celrep.2023.112524

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