DNA methylation dynamics during pregnancy

Pregnancy is a state of multiple physiological adaptations. Since methylation of DNA is an epigenetic mechanism that regulates gene expression and contributes to adaptive phenotypic variations, we investigated methylation changes in maternal blood of a longitudinal cohort of pregnant women from the...

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Autores principales: Fradin, Delphine, Tost, Jorg, Busato, Florence, Mille, Clémence, Lachaux, Fanny, Deleuze, Jean-François, Apter, Gisèle, Benachi, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242503/
https://www.ncbi.nlm.nih.gov/pubmed/37287456
http://dx.doi.org/10.3389/fcell.2023.1185311
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author Fradin, Delphine
Tost, Jorg
Busato, Florence
Mille, Clémence
Lachaux, Fanny
Deleuze, Jean-François
Apter, Gisèle
Benachi, Alexandra
author_facet Fradin, Delphine
Tost, Jorg
Busato, Florence
Mille, Clémence
Lachaux, Fanny
Deleuze, Jean-François
Apter, Gisèle
Benachi, Alexandra
author_sort Fradin, Delphine
collection PubMed
description Pregnancy is a state of multiple physiological adaptations. Since methylation of DNA is an epigenetic mechanism that regulates gene expression and contributes to adaptive phenotypic variations, we investigated methylation changes in maternal blood of a longitudinal cohort of pregnant women from the first trimester of gestation to the third. Interestingly, during pregnancy, we found a gain of methylation in genes involved in morphogenesis, such as ezrin, while we identified a loss of methylation in genes promoting maternal-infant bonding (AVP and PPP1R1B). Together, our results provide insights into the biological mechanisms underlying physiological adaptations during pregnancy.
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spelling pubmed-102425032023-06-07 DNA methylation dynamics during pregnancy Fradin, Delphine Tost, Jorg Busato, Florence Mille, Clémence Lachaux, Fanny Deleuze, Jean-François Apter, Gisèle Benachi, Alexandra Front Cell Dev Biol Cell and Developmental Biology Pregnancy is a state of multiple physiological adaptations. Since methylation of DNA is an epigenetic mechanism that regulates gene expression and contributes to adaptive phenotypic variations, we investigated methylation changes in maternal blood of a longitudinal cohort of pregnant women from the first trimester of gestation to the third. Interestingly, during pregnancy, we found a gain of methylation in genes involved in morphogenesis, such as ezrin, while we identified a loss of methylation in genes promoting maternal-infant bonding (AVP and PPP1R1B). Together, our results provide insights into the biological mechanisms underlying physiological adaptations during pregnancy. Frontiers Media S.A. 2023-05-22 /pmc/articles/PMC10242503/ /pubmed/37287456 http://dx.doi.org/10.3389/fcell.2023.1185311 Text en Copyright © 2023 Fradin, Tost, Busato, Mille, Lachaux, Deleuze, Apter and Benachi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Fradin, Delphine
Tost, Jorg
Busato, Florence
Mille, Clémence
Lachaux, Fanny
Deleuze, Jean-François
Apter, Gisèle
Benachi, Alexandra
DNA methylation dynamics during pregnancy
title DNA methylation dynamics during pregnancy
title_full DNA methylation dynamics during pregnancy
title_fullStr DNA methylation dynamics during pregnancy
title_full_unstemmed DNA methylation dynamics during pregnancy
title_short DNA methylation dynamics during pregnancy
title_sort dna methylation dynamics during pregnancy
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242503/
https://www.ncbi.nlm.nih.gov/pubmed/37287456
http://dx.doi.org/10.3389/fcell.2023.1185311
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