HIV DNA positively correlates with HLA-DR+CD8+ T lymphocytes over 8-year suppressive antiretroviral therapy

We studied the relationship between HIV DNA and CD8(+) T-cell activation in a retrospective cohort. We observed that the expression level of HLA-DR remained high in CD8(+) T-cells and was positively correlated with total HIV DNA [odds ratio (OR)  =  1.86, P = 0.028) during 8 years of suppressive ant...

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Detalles Bibliográficos
Autores principales: Zhu, Tianyuan, Cao, Wei, Li, Taisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242515/
https://www.ncbi.nlm.nih.gov/pubmed/37115824
http://dx.doi.org/10.1097/QAD.0000000000003587
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author Zhu, Tianyuan
Cao, Wei
Li, Taisheng
author_facet Zhu, Tianyuan
Cao, Wei
Li, Taisheng
author_sort Zhu, Tianyuan
collection PubMed
description We studied the relationship between HIV DNA and CD8(+) T-cell activation in a retrospective cohort. We observed that the expression level of HLA-DR remained high in CD8(+) T-cells and was positively correlated with total HIV DNA [odds ratio (OR)  =  1.86, P = 0.028) during 8 years of suppressive antiretroviral therapy (ART). This study illustrated the long-term interplay between HIV DNA reservoir and host inflammatory state despite viral suppression.
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spelling pubmed-102425152023-06-07 HIV DNA positively correlates with HLA-DR+CD8+ T lymphocytes over 8-year suppressive antiretroviral therapy Zhu, Tianyuan Cao, Wei Li, Taisheng AIDS Research Letter We studied the relationship between HIV DNA and CD8(+) T-cell activation in a retrospective cohort. We observed that the expression level of HLA-DR remained high in CD8(+) T-cells and was positively correlated with total HIV DNA [odds ratio (OR)  =  1.86, P = 0.028) during 8 years of suppressive antiretroviral therapy (ART). This study illustrated the long-term interplay between HIV DNA reservoir and host inflammatory state despite viral suppression. Lippincott Williams & Wilkins 2023-07-01 2023-04-20 /pmc/articles/PMC10242515/ /pubmed/37115824 http://dx.doi.org/10.1097/QAD.0000000000003587 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Research Letter
Zhu, Tianyuan
Cao, Wei
Li, Taisheng
HIV DNA positively correlates with HLA-DR+CD8+ T lymphocytes over 8-year suppressive antiretroviral therapy
title HIV DNA positively correlates with HLA-DR+CD8+ T lymphocytes over 8-year suppressive antiretroviral therapy
title_full HIV DNA positively correlates with HLA-DR+CD8+ T lymphocytes over 8-year suppressive antiretroviral therapy
title_fullStr HIV DNA positively correlates with HLA-DR+CD8+ T lymphocytes over 8-year suppressive antiretroviral therapy
title_full_unstemmed HIV DNA positively correlates with HLA-DR+CD8+ T lymphocytes over 8-year suppressive antiretroviral therapy
title_short HIV DNA positively correlates with HLA-DR+CD8+ T lymphocytes over 8-year suppressive antiretroviral therapy
title_sort hiv dna positively correlates with hla-dr+cd8+ t lymphocytes over 8-year suppressive antiretroviral therapy
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242515/
https://www.ncbi.nlm.nih.gov/pubmed/37115824
http://dx.doi.org/10.1097/QAD.0000000000003587
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AT litaisheng hivdnapositivelycorrelateswithhladrcd8tlymphocytesover8yearsuppressiveantiretroviraltherapy

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