Cargando…
Efficacy and Safety of Bempedoic Acid to Prevent Cardiovascular Events in Individuals at Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized-Control Trials
The purpose of this study was to evaluate the effectiveness and safety of bempedoic acid in preventing cardiovascular events among high-risk patients. We conducted a meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two independent re...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242672/ https://www.ncbi.nlm.nih.gov/pubmed/37288183 http://dx.doi.org/10.7759/cureus.38662 |
_version_ | 1785054269585489920 |
---|---|
author | Krishna Mohan, Gautham Varun Chenna, Venkata Sai Harshabhargav Tirumandyam, Gayathri Mian, Abdur Rehman Rashid, Atif Saleem, Faraz |
author_facet | Krishna Mohan, Gautham Varun Chenna, Venkata Sai Harshabhargav Tirumandyam, Gayathri Mian, Abdur Rehman Rashid, Atif Saleem, Faraz |
author_sort | Krishna Mohan, Gautham Varun |
collection | PubMed |
description | The purpose of this study was to evaluate the effectiveness and safety of bempedoic acid in preventing cardiovascular events among high-risk patients. We conducted a meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two independent researchers carried out online database searches on Medline, the Cochrane Library of Clinical Trials, and EMBASE until April 15, 2023, using search terms such as "bempedoic acid," "cardiovascular outcomes," and "randomized controlled trial." We also utilized medical subject heading (MeSH) terms and Boolean algebra operators to refine our search. We included articles that compared cardiovascular outcomes between patients receiving bempedoic acid and those receiving a placebo. The primary outcome assessed was major adverse cardiovascular events (MACE), defined as a composite of cardiovascular death, myocardial infarction, nonfatal stroke, hospitalization for unstable angina, and coronary revascularization. The meta-analysis included three randomized controlled trials with a total of 16,978 patients. The use of bempedoic acid was associated with a significant reduction in major adverse cardiovascular events. Individual analyses reported a low risk of myocardial infarction, coronary revascularization, and hospitalization due to unstable angina in patients receiving bempedoic acid. Furthermore, our meta-analysis found that bempedoic acid is a safe treatment option, as there was no significant difference between the bempedoic acid and placebo groups in terms of adverse events and serious adverse events. Our findings support the use of bempedoic acid as a promising treatment option for high-risk cardiovascular patients. However, since our meta-analysis included a limited number of studies with short follow-up periods, larger studies are necessary to provide more definitive evidence. |
format | Online Article Text |
id | pubmed-10242672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-102426722023-06-07 Efficacy and Safety of Bempedoic Acid to Prevent Cardiovascular Events in Individuals at Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized-Control Trials Krishna Mohan, Gautham Varun Chenna, Venkata Sai Harshabhargav Tirumandyam, Gayathri Mian, Abdur Rehman Rashid, Atif Saleem, Faraz Cureus Cardiology The purpose of this study was to evaluate the effectiveness and safety of bempedoic acid in preventing cardiovascular events among high-risk patients. We conducted a meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two independent researchers carried out online database searches on Medline, the Cochrane Library of Clinical Trials, and EMBASE until April 15, 2023, using search terms such as "bempedoic acid," "cardiovascular outcomes," and "randomized controlled trial." We also utilized medical subject heading (MeSH) terms and Boolean algebra operators to refine our search. We included articles that compared cardiovascular outcomes between patients receiving bempedoic acid and those receiving a placebo. The primary outcome assessed was major adverse cardiovascular events (MACE), defined as a composite of cardiovascular death, myocardial infarction, nonfatal stroke, hospitalization for unstable angina, and coronary revascularization. The meta-analysis included three randomized controlled trials with a total of 16,978 patients. The use of bempedoic acid was associated with a significant reduction in major adverse cardiovascular events. Individual analyses reported a low risk of myocardial infarction, coronary revascularization, and hospitalization due to unstable angina in patients receiving bempedoic acid. Furthermore, our meta-analysis found that bempedoic acid is a safe treatment option, as there was no significant difference between the bempedoic acid and placebo groups in terms of adverse events and serious adverse events. Our findings support the use of bempedoic acid as a promising treatment option for high-risk cardiovascular patients. However, since our meta-analysis included a limited number of studies with short follow-up periods, larger studies are necessary to provide more definitive evidence. Cureus 2023-05-07 /pmc/articles/PMC10242672/ /pubmed/37288183 http://dx.doi.org/10.7759/cureus.38662 Text en Copyright © 2023, Krishna Mohan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Cardiology Krishna Mohan, Gautham Varun Chenna, Venkata Sai Harshabhargav Tirumandyam, Gayathri Mian, Abdur Rehman Rashid, Atif Saleem, Faraz Efficacy and Safety of Bempedoic Acid to Prevent Cardiovascular Events in Individuals at Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized-Control Trials |
title | Efficacy and Safety of Bempedoic Acid to Prevent Cardiovascular Events in Individuals at Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized-Control Trials |
title_full | Efficacy and Safety of Bempedoic Acid to Prevent Cardiovascular Events in Individuals at Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized-Control Trials |
title_fullStr | Efficacy and Safety of Bempedoic Acid to Prevent Cardiovascular Events in Individuals at Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized-Control Trials |
title_full_unstemmed | Efficacy and Safety of Bempedoic Acid to Prevent Cardiovascular Events in Individuals at Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized-Control Trials |
title_short | Efficacy and Safety of Bempedoic Acid to Prevent Cardiovascular Events in Individuals at Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized-Control Trials |
title_sort | efficacy and safety of bempedoic acid to prevent cardiovascular events in individuals at risk of cardiovascular diseases: a meta-analysis of randomized-control trials |
topic | Cardiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242672/ https://www.ncbi.nlm.nih.gov/pubmed/37288183 http://dx.doi.org/10.7759/cureus.38662 |
work_keys_str_mv | AT krishnamohangauthamvarun efficacyandsafetyofbempedoicacidtopreventcardiovasculareventsinindividualsatriskofcardiovasculardiseasesametaanalysisofrandomizedcontroltrials AT chennavenkatasaiharshabhargav efficacyandsafetyofbempedoicacidtopreventcardiovasculareventsinindividualsatriskofcardiovasculardiseasesametaanalysisofrandomizedcontroltrials AT tirumandyamgayathri efficacyandsafetyofbempedoicacidtopreventcardiovasculareventsinindividualsatriskofcardiovasculardiseasesametaanalysisofrandomizedcontroltrials AT mianabdurrehman efficacyandsafetyofbempedoicacidtopreventcardiovasculareventsinindividualsatriskofcardiovasculardiseasesametaanalysisofrandomizedcontroltrials AT rashidatif efficacyandsafetyofbempedoicacidtopreventcardiovasculareventsinindividualsatriskofcardiovasculardiseasesametaanalysisofrandomizedcontroltrials AT saleemfaraz efficacyandsafetyofbempedoicacidtopreventcardiovasculareventsinindividualsatriskofcardiovasculardiseasesametaanalysisofrandomizedcontroltrials |