Catalytic Cycle of the Bifunctional Enzyme Phosphoribosyl-ATP Pyrophosphohydrolase/Phosphoribosyl-AMP Cyclohydrolase

[Image: see text] The bifunctional enzyme phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-AMP cyclohydrolase (HisIE) catalyzes the second and third steps of histidine biosynthesis: pyrophosphohydrolysis of N(1)-(5-phospho-β-D-ribosyl)-ATP (PRATP) to N(1)-(5-phospho-β-D-ribosyl)-AMP (PRAMP) an...

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Detalles Bibliográficos
Autores principales: Fisher, Gemma, Pečaver, Ennio, Read, Benjamin J., Leese, Susannah K., Laing, Erin, Dickson, Alison L., Czekster, Clarissa M., da Silva, Rafael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242683/
https://www.ncbi.nlm.nih.gov/pubmed/37288093
http://dx.doi.org/10.1021/acscatal.3c01111

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